ArticleNature2024
Position-dependent function of human sequence-specific transcription factors.
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In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47citing papers in PubMed
–field-weighted citation impact
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Who cites it
47 citing papers in PubMed.
- Prioritizing context-specific genetic risk mechanisms in 11 solid cancers.Journal of the National Cancer Institute · 2026Article
- Identifying independent causal cell types for human diseases and risk variants.Cell genomics · 2026Article
- The molecular basis of transcription initiation by RNA polymerase II.Nature reviews. Molecular cell biology · 2026Review
- High-throughput functional characterization of enhancers in totipotent-like cells.Nature communications · 2026Article
- Synthetic transcriptional repression systems in plants.Plant cell reports · 2026Review
- Intrinsic and non-cell-autonomous roles for the neurodevelopmental syndrome-linked transcription factor UNC-3/EBF.Nature communications · 2026Article
- A deep learning model captures position-specific effects of plant regulatory sequences and suggests genes under complex regulation.Plant physiology · 2026Article
- Transcription clusters and developmental pathways - nature, nurture, noise.Journal of cell science · 2026Review
- The nascent transcriptome delineates the regulatory landscape in human health and disease.bioRxiv : the preprint server for biology · 2026Article
- Profiling active RNA polymerase II transcription start sites from total RNA by capped small RNA sequencing (csRNA-seq).Nature protocols · 2026Review
- Article
- Transcription Start Site Choice Regulates mGenes · 2026Article
- Transcription initiation profiling defines the regulatory logic of astrocyte gene regulation.bioRxiv : the preprint server for biology · 2026Article
- Continuous negative autoregulation fine-tunes dosage-sensitive transcription factor expression to maintain post-mitotic neuron identity.bioRxiv : the preprint server for biology · 2026Article
- Decoding cis-regulatory elements in the germline of the human malaria vector Anopheles gambiae.Communications biology · 2026Article
- STARR-CRAAVT: A platform to identify cell type-specific regulatory elements for next-generation gene therapy.iScience · 2026Article
- Transcription factors Lef1 and Rest stimulate recovery from depressive states.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Altered benzo[a]pyrene adduct formation in nucleosomes establishes distinct mutational patterns in lung cancer.The Journal of biological chemistry · 2026Article
- Article
- Allele-specific alternative polyadenylation links noncoding genetic variation to Alzheimer's disease risk.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Sascha H DuttkeSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, USA. sascha.duttke@wsu.edu.ORCID 0000-0003-4717-000X
Carlos GuzmanDepartment of Medicine, Division of Endocrinology, U.C. San Diego School of Medicine, La Jolla, CA, USA.
Max ChangDepartment of Medicine, Division of Endocrinology, U.C. San Diego School of Medicine, La Jolla, CA, USA.ORCID 0000-0002-4526-489X
Nathaniel P Delos SantosDepartment of Medicine, Division of Endocrinology, U.C. San Diego School of Medicine, La Jolla, CA, USA.
Bayley R McDonaldSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, USA.ORCID 0009-0003-6148-5689
Jialei XieDepartment of Pathology and Medicine, U.C. San Diego School of Medicine, La Jolla, CA, USA.
Aaron F CarlinDepartment of Pathology and Medicine, U.C. San Diego School of Medicine, La Jolla, CA, USA.ORCID 0000-0002-1669-8066
Sven HeinzDepartment of Medicine, Division of Endocrinology, U.C. San Diego School of Medicine, La Jolla, CA, USA. sheinz@health.ucsd.edu.ORCID 0000-0002-4665-1007
Christopher BennerDepartment of Medicine, Division of Endocrinology, U.C. San Diego School of Medicine, La Jolla, CA, USA. cbenner@health.ucsd.edu.ORCID 0000-0002-4618-0719
Funding
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MSARS-CoV adaptations through a Systems Biology Lens (SYBIL)U19AI135972 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Adolfo Garcia-Sastre · 2018 to 2026
$27.2MVirus CoreU19AI106754 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2013 to 2017
$26.0MTissue-specific roles of FXR in CVD and NASHP01HL147835 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WITZTUM, JOSEPH L. · 2020 to 2024
$12.2MSan Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8MSan Diego Biomedical Informatics Education & Research (SABER)T15LM011271 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHAMIM NEMATI · 2012 to 2026
$9.7MDynamic regulatory network models of human response to influenza virusU01AI150748 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI MARAZZI, IVAN, MIRALDI, EMILY · 2020 to 2024
$5.8MNovel SETD5-based Molecular Mechanisms and Therapeutic Tools to Understand and Revert Neuronal Dysfunction Associated with Intellectual disability and AutismR01MH127077 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Alon Goren, Alysson R. Muotri · 2022 to 2026
$3.9MDecoding the grammar of transcriptional enhancers regulating different stages of opioid use disorderU01DA051972 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BENNER, CHRISTOPHER W, TELESE, FRANCESCA · 2020 to 2024
$3.4MUncovering how transcription and chromatin 3D structure impact one another during cellular activationR01GM134366 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BENNER, CHRISTOPHER W · 2019 to 2023
$1.7MHow transcription disrupts genome 3D organizationR01GM129523 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEINZ, SVEN W · 2020 to 2023
$1.3MMultiscale genomic decryption of regulatory DNAR35GM149520 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Christopher W Benner · 2024 to 2026
$1.2MNHGRI NIH HHS F31 HG011823NHLBI NIH HHS P01 HL147835NIAID NIH HHS K08 AI130381NIAID NIH HHS U01 AI150748NIAID NIH HHS U19 AI106754NIAID NIH HHS U19 AI135972NIDA NIH HHS R21 DA056177NIDA NIH HHS U01 DA051972NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK120515NIGMS NIH HHS R00 GM135515NIGMS NIH HHS R01 GM129523NIGMS NIH HHS R01 GM134366NIGMS NIH HHS R35 GM149520NIH HHS S10 OD026929NIMH NIH HHS R01 MH127077NLM NIH HHS T15 LM011271
Abstract
Patterns of transcriptional activity are encoded in our genome through regulatory elements such as promoters or enhancers that, paradoxically, contain similar assortments of sequence-specific transcription factor (TF) binding sites
Indexed as
Gene Expression RegulationNucleotide MotifsPromoter Regions, GeneticTranscription FactorsTranscription Initiation, GeneticTranscription Initiation SiteBinding SitesCCAAT-Binding FactorGenetic VariationGenome, HumanHumansNuclear Respiratory Factor 1Protein BindingSp1 Transcription FactorCCAAT-Binding FactorNRF1 protein, humannuclear factor YNuclear Respiratory Factor 1SP1 protein, humanSp1 Transcription FactorTranscription Factors
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.