Evidence map›Paper›PMID 39020071›Full record

ReviewCommunications biology2024

Overcoming big bottlenecks in vascular regeneration.

Dalia A Fantini, Guang Yang, Astha Khanna, Divya Subramanian, Julie A Phillippi, Ngan F Huang

Abstract readReview
In one paragraph

Review in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Targeting Arterial Dysfunction in Cardiovascular Disease Using Stem Cell-Based Therapies.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  4. Direct in vivo reprogramming to relieve tissue ischemia via induced vasculogenesis.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  5. Article
  6. Article
  7. Towards advanced regenerative therapeutics to tackle cardio-cerebrovascular diseases.American heart journal plus : cardiology research and practice · 2025
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dalia A FantiniDepartment of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0009-0002-7569-9162
Guang YangDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Astha KhannaGraver Technologies, Newark, NJ, USA.
Divya SubramanianDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, USA.
Julie A PhillippiDepartment of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA. phillippija@upmc.edu.ORCID 0000-0002-9879-2039
Ngan F HuangDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA. ngantina@stanford.edu.ORCID 0000-0003-2298-6790

Funding

Matrix biophysics and pericyte mechanobiology in (patho)physiological angiogenesisR01HL162822 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Amrinder Nain, Julie A Phillippi · 2023 to 2026
$2.3M
Matrix mediated vasa vasorum dysfunction in thoracic aortic diseaseR01HL131632 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PHILLIPPI, JULIE A · 2017 to 2021
$1.9M
Engineered matrix microarrays to enhance the regenerative potential of iPSC-derived endothelial cellsR01HL142718 · NHLBI · STANFORD UNIVERSITY · PI HEILSHORN, SARAH C, HUANG, NGAN F. · 2018 to 2021
$1.6M
Biomaterials for delivery and maintenance of tip endothelial cellsR21HL172096 · NHLBI · UNIVERSITY OF CALIFORNIA, MERCED · PI HUANG, NGAN F., MCCLOSKEY, KARA E · 2024 to 2025
$643k
Novel Highly Regenerative and Scalable Progenitor Cell Exosomes for Treating Peripheral Artery DiseaseR41HL170875 · NHLBI · SERINA THERAPEUTICS, INC. · PI HUANG, NGAN F., LEE, JI EUN · 2023 to 2023
$341k
Engineering Vascularized Skeletal Muscle for Treatment of Volumetric Muscle LossI01BX004259 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI Ngan F. Huang · 2019 to 2026
–
BLRD Research Career Scientist Award ApplicationIK6BX006309 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI HUANG, NGAN F. · 2023 to 2025
–
BLRD VA I01 BX004259BLRD VA IK6 BX006309National Science Foundation (NSF) 1829534 and 2227614NHLBI NIH HHS R01 HL142718NHLBI NIH HHS R21 HL172096NHLBI NIH HHS R41 HL170875U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01 R01 HL142718, R41 HL170875, and R21 HL172096-01U.S. Department of Veterans Affairs (Department of Veterans Affairs) 1I01BX004259 and IK6BX006309
6 · The paper itself

Abstract

Bioengineering and regenerative medicine strategies are promising for the treatment of vascular diseases. However, current limitations inhibit the ability of these approaches to be translated to clinical practice. Here we summarize some of the big bottlenecks that inhibit vascular regeneration in the disease applications of aortic aneurysms, stroke, and peripheral artery disease. We also describe the bottlenecks preventing three-dimensional bioprinting of vascular networks for tissue engineering applications. Finally, we describe emerging technologies and opportunities to overcome these challenges to advance vascular regeneration.

Indexed as

RegenerationRegenerative MedicineTissue EngineeringAnimalsBioprintingBlood VesselsHumansPrinting, Three-DimensionalVascular Diseases

Identifiers

PMID39020071
PMCPMC11255241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.