Evidence map›Paper›PMID 39019981›Full record

ArticleScientific reports2024

Association between eating speed and atherosclerosis in relation to growth differentiation factor-15 levels in older individuals in a cross-sectional study.

Yuji Shimizu, Shin-Ya Kawashiri, Yuko Noguchi, Nagisa Sasaki, Mutsumi Matsuyama, Seiko Nakamichi, Kazuhiko Arima, Yasuhiro Nagata, Takahiro Maeda, Naomi Hayashida

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuji ShimizuEpidemiology Section, Division of Public Health, Osaka Institute of Public Health, Osaka, 537-0025, Japan. simizu@iph.osaka.jp.
Shin-Ya KawashiriDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8523, Japan.
Yuko NoguchiDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8523, Japan.
Nagisa SasakiEpidemiology Section, Division of Public Health, Osaka Institute of Public Health, Osaka, 537-0025, Japan.
Mutsumi MatsuyamaDivision of Strategic Collaborative Research, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan.
Seiko NakamichiDepartment of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8523, Japan.
Kazuhiko ArimaLeading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8523, Japan.
Yasuhiro NagataDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8523, Japan.
Takahiro MaedaDepartment of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8523, Japan.
Naomi HayashidaLeading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8523, Japan.

Funding

Japan Society for the Promotion of Science 21H02575Japan Society for the Promotion of Science 22K06421
6 · The paper itself

Abstract

Although fast eating speed has been associated with cardiovascular risk factors, no studies have reported an association between fast eating speed and atherosclerosis as evaluated by carotid intima-media thickness (CIMT). Rapid glucose ingestion is known to cause glucose spikes, which may accelerate atherogenesis and increase levels of growth differentiation factor 15 (GDF-15). Therefore, GDF-15 levels may influence the association between fast eating speed and atherosclerosis. To evaluate the association between eating speed and atherosclerosis in relation to GDF-15, this cross-sectional study analyzed 742 Japanese aged 60-69 years. They were required to have normal thyroid hormone levels, because both GDF-15 levels and atherosclerosis (CIMT ≥ 1.1 mm) can be influenced by thyroid dysfunction. Participants were stratified by the median GDF-15 level. A significant positive association was observed between fast eating speed and atherosclerosis, but only among participants with a high GDF-15 level: the sex- and age-adjusted odds ratios (95% confidence intervals) were 1.95 (1.09, 3.48) in participants with a high GDF-15 level, and 0.83 (0.37, 1.88) in those with a low GDF-15 level. This association remained even after further adjustment for thyroid function and metabolic factors. Serum concentrations of GDF-15 may mediate the association between fast eating speed and atherosclerosis.

Indexed as

AtherosclerosisCarotid Intima-Media ThicknessGrowth Differentiation Factor 15AgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedRisk FactorsGDF15 protein, humanGrowth Differentiation Factor 15

Identifiers

PMID39019981
PMCPMC11255208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.