Evidence map›Paper›PMID 39019884›Full record

ArticleNature communications2024

Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss.

Kyuto Sonehara, Yoshitaka Yano, Tatsuhiko Naito, Shinobu Goto, Hiroyuki Yoshihara, Takahiro Otani, Fumiko Ozawa, Tamao Kitaori, Biobank Japan Project, Koichi Matsuda and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. A Genome-Wide Association Study RevealsJournal of arrhythmia · 2026
    Article
  9. Loss of Function of theCurrent issues in molecular biology · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Evaluation ofCurrent protein & peptide science · 2026
    Article
  14. Genetic Variants in Recurrent Euploid Pregnancy Loss.medRxiv : the preprint server for health sciences · 2025
    Article
  15. Article
  16. Genetic Associations ofInternational journal of molecular sciences · 2025
    Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kyuto Sonehara *Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.ORCID 0000-0002-4536-1761
Yoshitaka Yano *Department of Obstetrics and Gynecology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Tatsuhiko NaitoDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Suita, Japan.ORCID 0000-0002-2779-4600
Shinobu GotoDepartment of Obstetrics and Gynecology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Hiroyuki YoshiharaDepartment of Obstetrics and Gynecology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.ORCID 0000-0001-9306-2849
Takahiro OtaniDepartment of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Fumiko OzawaDepartment of Obstetrics and Gynecology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Tamao KitaoriDepartment of Obstetrics and Gynecology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Biobank Japan Project
Koichi MatsudaLaboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.ORCID 0000-0001-7292-2686
Takashi NishiyamaDepartment of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Yukinori OkadaDepartment of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan. yuki-okada@m.u-tokyo.ac.jp.ORCID 0000-0002-0311-8472
Mayumi Sugiura-OgasawaraDepartment of Obstetrics and Gynecology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. og.mym@med.nagoya-cu.ac.jp.ORCID 0000-0002-2265-377X

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 23K14451;23K08850;22H00476
6 · The paper itself

Abstract

Recurrent pregnancy loss (RPL) is a major reproductive health issue with multifactorial causes, affecting 2.6% of all pregnancies worldwide. Nearly half of the RPL cases lack clinically identifiable causes (e.g., antiphospholipid syndrome, uterine anomalies, and parental chromosomal abnormalities), referred to as unexplained RPL (uRPL). Here, we perform a genome-wide association study focusing on uRPL in 1,728 cases and 24,315 female controls of Japanese ancestry. We detect significant associations in the major histocompatibility complex (MHC) region at 6p21 (lead variant=rs9263738; P = 1.4 × 10

Indexed as

Abortion, HabitualGenetic Predisposition to DiseaseGenome-Wide Association StudyAdultAllelesCase-Control StudiesChromosomes, Human, Pair 6DNA Copy Number VariationsFemaleGene FrequencyGenetic VariationHaplotypesHLA-B AntigensHLA-C AntigensHLA-DRB1 ChainsHumansHLA-B AntigensHLA-C AntigensHLA-DRB1 Chains

Identifiers

PMID39019884
PMCPMC11255296

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.