Evidence map›Paper›PMID 39019601›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Late-onset Neutropenia after Rituximab Treatment for MPO-ANCA-associated Vasculitis.

Kentaro Watanabe, Noriaki Shimada, Motoko Kanzaki, Kosuke Fukuoka, Kenichiro Asano

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kentaro WatanabeDepartment of Nephrology, Kurashiki Central Hospital, Japan.
Noriaki ShimadaDepartment of Nephrology, Kurashiki Central Hospital, Japan.
Motoko KanzakiDepartment of Nephrology, Kurashiki Central Hospital, Japan.
Kosuke FukuokaDepartment of Nephrology, Kurashiki Central Hospital, Japan.
Kenichiro AsanoDepartment of Nephrology, Kurashiki Central Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An underestimated side effect of rituximab is late-onset neutropenia (R-LON), which often resolves spontaneously and rarely results in a severe infection. We herein report a case of febrile neutropenia due to R-LON in a 91-year-old woman with renal failure who was treated with rituximab to induce remission of myeloperoxidase antineutrophil cytoplasmic antibodies-associated vasculitis. Fifty-four days after the last rituximab administration, the patient was hospitalized for febrile neutropenia due to R-LON, which improved with granulocyte colony-stimulating factor and antibiotics. Although R-LON may resolve spontaneously and remain unnoticed, it can cause severe infections in the elderly and patients with renal failure.

Indexed as

Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisNeutropeniaPeroxidaseRituximabAged, 80 and overAntibodies, Antineutrophil CytoplasmicFemaleHumansAntibodies, Antineutrophil CytoplasmicPeroxidaseRituximabelderlylate-onset neutropeniaMPO-ANCA-associated vasculitisrenal failurerituximab

Identifiers

PMID39019601
PMCPMC11904456

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.