ArticleBMJ (Clinical research ed.)2024
Covid-19 infection and vaccination during first trimester and risk of congenital anomalies: Nordic registry based study.
Article in BMJ (Clinical research ed.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Safety of BNT162b2 COVID-19 Vaccine in Pregnancy: A Systematic Review.Infectious diseases and therapy · 2026Pooled it
- From discovery through emergency use to the present: Safety evaluation of the COVID-19 mRNA-1273 (Moderna) vaccine.Human vaccines & immunotherapeutics · 2026Review
- Functionalized bio-patches for intra-abdominal applications.iScience · 2026Review
- Preparedness for maternal and offspring health surveillance in pandemics: Lessons learned from studies on COVID-19 using Scandinavian registry data.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Neonatal and Infant Health Outcomes Following Maternal COVID-19 Vaccination: CDC's COVID-19 Vaccine Pregnancy Registry.Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners · 2026Article
- Large population-based assessment of SARS-CoV-2 teratogenicity by profiling congenital anomalies during COVID-19 pandemic.Journal of the Turkish German Gynecological Association · 2026Article
- Background incidence rates and observed-to-expected ratios of adverse events of special interest after covid-19 mRNA vaccination during pregnancy in France: a nationwide population-based study.The Lancet regional health. Europe · 2026Article
- Global, regional, and national burden and trends of congenital birth defects from 1990 to 2021: epidemiological trends, health inequalities, and COVID-19 impact.Translational pediatrics · 2026Article
- COVID-19 and Congenital Cleft Lip and Palate: A Systematic Review Focusing on Nonsyndromic Neonatal Outcomes.Cureus · 2026Review
- Association Between Congenital Gastrointestinal Malformation Outcome and Largely Asymptomatic SARS-CoV-2 Infection in Pediatric Patients-A Systematic Review.Journal of clinical medicine · 2025Review
- First-Trimester mRNA COVID-19 Vaccination and Risk of Major Congenital Anomalies.JAMA network open · 2025Article
- Prenatal Ultrasound Diagnosis of Binder Phenotype: Case Series of Seven Patients and Literature Review.Reports (MDPI) · 2025Article
- Maternal Exposures to COVID-19 Vaccine and Adverse Birth Outcomes: National Population Study in Korea.Journal of Korean medical science · 2025Article
- COVID-19 Vaccination During Pregnancy and Birth Defects: Results From the CDC COVID-19 Vaccine Pregnancy Registry, United States 2021-2022.Birth defects research · 2025Article
- Article
- How to Manage a Neonate Born from a SARS-CoV-2-Positive Mother: A Narrative Review.Pathogens (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the risk of major congenital anomalies according to infection with or vaccination against covid-19 during the first trimester of pregnancy.
designProspective Nordic registry based study.
settingSweden, Denmark, and Norway.
participants343 066 liveborn singleton infants in Sweden, Denmark, and Norway, with an estimated start of pregnancy between 1 March 2020 and 14 February 2022, identified using national health registries.
main outcome measureMajor congenital anomalies were categorised using EUROCAT (European Surveillance of Congenital Anomalies) definitions. The risk after covid-19 infection or vaccination during the first trimester was assessed by logistic regression, adjusting for maternal age, parity, education, income, country of origin, smoking, body mass index, chronic conditions, and estimated date of start of pregnancy.
results17 704 (5.2%) infants had a major congenital anomaly. When evaluating risk associated with covid-19 infection during the first trimester, the adjusted odds ratio ranged from 0.84 (95% confidence interval 0.51 to 1.40) for eye anomalies to 1.12 (0.68 to 1.84) for oro-facial clefts. Similarly, the risk associated with covid-19 vaccination during the first trimester ranged from 0.84 (0.31 to 2.31) for nervous system anomalies to 1.69 (0.76 to 3.78) for abdominal wall defects. Estimates for 10 of 11 subgroups of anomalies were less than 1.04, indicating no notable increased risk.
conclusionsCovid-19 infection and vaccination during the first trimester of pregnancy were not associated with risk of congenital anomalies.
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