ArticleHeart (British Cardiac Society)2024
Evaluation of the World Health Organization-HEARTS hypertension control package in Bangladesh: a quasi-experimental trial.
Article in Heart (British Cardiac Society), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04992039 (Evaluation of the WHO HEARTS Hypertension Control Package in the Primary Care Clinics of Bangladesh), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the WHO HEARTS Hypertension Control Package in the Primary Care Clinics of Bangladesh: A Quasi-experimental Trial
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness and Safety of Using Standardized Treatment Protocols for Hypertension Compared to Usual Care: A Meta-Analysis of Randomized Clinical Trials.Journal of clinical hypertension (Greenwich, Conn.) · 2025Pooled it
- Implementation outcomes from the Hypertension Treatment in Nigeria program: results from a type 2 hybrid interrupted time series trial.Implementation science : IS · 2025Trial
- Integration of Cardiovascular Disease Services within Primary Health Care Systems: Insights from South Asia.Current atherosclerosis reports · 2026Review
- Bridging Equity Gaps in Maternal and NCD Services: Policy Priorities for Bangladesh's Evolving Health Landscape.Health science reports · 2026Article
- Evaluating implementation of the HEARTS model for management of hypertension and diabetes in Guatemala: protocol for a prospective observational hybrid type 3 study.Implementation science communications · 2026Article
- Strategic Reform for the Non-Communicable Disease Crisis in Bangladesh: A Narrative Review of Policy Drivers and Systemic Solutions.Health science reports · 2026Article
- Global trends in hypertension prevalence, awareness, treatment, and control.Current opinion in nephrology and hypertension · 2026Review
- Hypertension Control in Bangladesh: Changes, Sociodemographic Variation, and Socioeconomic Inequality from the 2017-18 to 2022 Bangladesh Demographic and Health Surveys.Global heart · 2026Article
- Global Burden of Ischemic Heart Disease and Ischemic Stroke, 1990-2023: Spatial Heterogeneity, SDI Inequalities, Pandemic-Era Inflections, and Scenario Forecasts to 2035 Using GBD 2023.Cardiology research and practice · 2026Article
- Bridging Hypertension Care Shortfalls Between Provider Capacity and Patient Needs: A Pooled Analysis of Data From 199 Countries and Territories.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Article
- Unlocking health equity by eliminating copayments for essential antihypertensive medications.EClinicalMedicine · 2025Review
- Calcium Channel Blockers: Key Medicine to Drive Global Hypertension Control.Global heart · 2025Article
- Evaluating the World Health Organization's Hearts Model for Hypertension and Diabetes Management: A Pilot Implementation Study in Guatemala.Global heart · 2025Article
- Evaluating the World Health Organization's HEARTS Model for Hypertension and Diabetes Management: A Pilot Implementation Study in Guatemala.medRxiv : the preprint server for health sciences · 2024Article
- Integrated Antihypertensive and Statin Treatment Protocols for Cardiovascular Disease Prevention in Low- and Middle-Income Countries.Global heart · 2024Article
Corrections and comments
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe World Health Organization (WHO) promotes the HEARTS technical package for improving hypertension control worldwide, but its effectiveness has not been rigorously evaluated.
objectiveTo compare hypertension outcomes in clinics implementing HEARTS versus clinics continuing usual hypertension care in rural Bangladesh.
methodsA matched-pair cluster quasi-experimental trial in Upazila Health Complexes (UHCs; primary healthcare facilities) was conducted in rural Bangladesh. A total of 3935 patients (mean age 52.3 years, 70.5% female) with uncontrolled hypertension (blood pressure (BP) ≥140/90 mm Hg regardless of treatment history) were enrolled: 1950 patients from 7 HEARTS UHCs and 1985 patients from 7 matched usual care UHCs. The primary outcome was systolic BP at 6 months measured at the patient's home; secondary outcomes were diastolic BP, hypertension control rate (<140/90 mm Hg) and loss to follow-up. Multivariable mixed-effects linear and Poisson models were conducted.
resultsBaseline mean systolic BP was 158.4 mm Hg in the intervention group and 158.8 mm Hg in the usual care group. At 6 months, 95.5% of participants completed follow-up. Compared with usual care, the intervention significantly lowered systolic BP (-23.7 mm Hg vs -20.0 mm Hg; net difference -3.7 mm Hg (95% CI -5.1 to -2.2)) and diastolic BP (-10.2 mm Hg vs -8.3 mm Hg; net difference -1.9 mm Hg (95% CI -2.7 to -1.1)) and improved hypertension control (62.0% vs 49.7%, net difference 12.3% (95% CI 9.0 to 16.8)). Rate of missed clinic visits was lower in the intervention group (8.8% vs 39.3%, p<0.001).
conclusionsAfter WHO-HEARTS package implementation in rural Bangladesh, BP was lowered and hypertension control improved significantly compared with usual care. TRIAL REGISTRATION NUMBER: NCT04992039.
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