Evidence map›Paper›PMID 39019353›Full record

Observational studyThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2025

Long-term air pollution exposure and the risk of primary graft dysfunction after lung transplantation.

Tatsuki Koyama, Zhiguo Zhao, John R Balmes, Carolyn S Calfee, Michael A Matthay, John P Reilly, Mary K Porteous, Joshua M Diamond, Jason D Christie, Edward Cantu and 2 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tatsuki KoyamaDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
Zhiguo ZhaoDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
John R BalmesDepartment of Medicine, University of California, San Francisco, California.
Carolyn S CalfeeDepartment of Medicine, University of California, San Francisco, California; Department of Anesthesia and Cardiovascular Research Institute, University of California, San Francisco, California.
Michael A MatthayDepartment of Medicine, University of California, San Francisco, California; Department of Anesthesia and Cardiovascular Research Institute, University of California, San Francisco, California.
John P ReillyDivision of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Mary K PorteousDivision of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Joshua M DiamondDivision of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Jason D ChristieDivision of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Center for Translational Lung Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Edward CantuDivision of Cardiovascular Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Lorraine B WareDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: Lorraine.ware@vumc.org.
Lung Transplant Outcomes Group

Funding

Long Term Follow up of the Lung Transplant Outcomes Group CohortU01HL145435 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHRISTIE, JASON D, PALMER, SCOTT M · 2019 to 2025
$10.2M
Clinical Risk Factors for Primary Graft DysfunctionR01HL087115 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHRISTIE, JASON D · 2007 to 2017
$7.1M
Precision Medicine in the Acute Respiratory Distress SyndromeR35HL140026 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2018 to 2024
$6.8M
Objective Lung Assessment Tools for Improved Organ Use in Lung TransplantationR01HL155821 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CANTU, EDWARD · 2021 to 2025
$3.0M
The GOLD Study: Goal of Open Lung Ventilation in DonorsR01HL126176 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WARE, LORRAINE B · 2015 to 2020
$2.8M
Peri-operative factors that drive cell-free hemoglobin-mediated primary graft dysfunctionU01HL163303 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ciara M Shaver · 2022 to 2026
$2.3M
Mentored Patient Oriented Research in Lung TransplantationK24HL115354 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHRISTIE, JASON D · 2012 to 2021
$1.2M
NHLBI NIH HHS K24 HL115354NHLBI NIH HHS R01 HL087115NHLBI NIH HHS R01 HL126176NHLBI NIH HHS R01 HL155821NHLBI NIH HHS R35 HL140026NHLBI NIH HHS U01 HL145435NHLBI NIH HHS U01 HL163303
6 · The paper itself

Abstract

backgroundPrimary graft dysfunction (PGD) contributes substantially to both short- and long-term mortality after lung transplantation, but the mechanisms that lead to PGD are not well understood. Exposure to ambient air pollutants is associated with adverse events during waitlisting for lung transplantation and chronic lung allograft dysfunction, but its association with PGD has not been studied. We hypothesized that long-term exposure of the lung donor and recipient to high levels of ambient air pollutants would increase the risk of PGD in lung transplant recipients.

methodsUsing data from 1428 lung transplant recipients and their donors enrolled in the Lung Transplant Outcomes Group observational cohort study, we evaluated the association between the development of PGD and zip-code-based estimates of long-term exposure to 6 major air pollutants (ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide, particulate matter 2.5, and particulate matter 10) in both the lung donor and the lung recipient. Exposure estimates used daily EPA air pollutant monitoring data and were based on the geographic centroid of each subject's residential zip code. Associations were tested in both univariable and multivariable models controlling for known PGD risk factors.

resultsWe did not find strong associations between air pollutant exposures in either the donor or the recipient and PGD.

conclusionsExposure to ambient air pollutants, at the levels observed in this study, may not be sufficiently harmful to prime the donor lung or the recipient to develop PGD, particularly when considering the robust associations with other established PGD risk factors.

Indexed as

Air PollutionLung TransplantationPrimary Graft DysfunctionAdultAir PollutantsEnvironmental ExposureFemaleFollow-Up StudiesHumansMaleMiddle AgedRisk FactorsTime FactorsUnited StatesAir Pollutantsacute lung injuryair pollutionlung transplantationozoneprimary graft dysfunction

Identifiers

PMID39019353
PMCPMC12118639

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.