Trial reportThe Journal of nutrition2024
The Effect of Dietary Nitrate on the Oral Microbiome and Salivary Biomarkers in Individuals with High Blood Pressure.
Trial report in The Journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Lowering salivary pH with sugar-containing gum augments salivary nitrite production and blood pressure reduction with dietary nitrate (beetroot juice).British journal of clinical pharmacology · 2026Trial
- Review
- The Impact of Oral-Gut Microbiota Structure and Its Manipulation on RA Development and Management.Food science & nutrition · 2026Review
- Review
- Exploring the associations between dietary nitrate and nitrite intake and markers of self-reported periodontal disease in the UK Biobank cohort.European journal of nutrition · 2026Article
- The Oral Microbiome-Nitrate-Nitrite-Nitric Oxide Axis and Cardiovascular Health: A Narrative Review.Journal of clinical medicine · 2026Review
- Beetroot Juice Enhances Nitrate Metabolism and Endothelial Function but Not Cardiovascular or Strength Performance in Bodybuilders with a History of Anabolic-Androgenic Steroid Abuse: A Crossover Trial.Antioxidants (Basel, Switzerland) · 2026Article
- Influence of exercise training on nitric oxide pathways and their physiological effects.Redox biology · 2026Review
- Probiotics, Prebiotics, Synbiotics, Postbiotics, and Bioactive Agents in Modulating Harmful Oral Biofilms.Probiotics and antimicrobial proteins · 2026Review
- Diet-Microbiome Analysis in a Healthy Cohort Reveals Potential Role of Intestinal Microbiota in Metabolism.bioRxiv : the preprint server for biology · 2026Article
- The compartmentalization model of nitrate homeostasis: Role of the salivary glands, skeletal muscle, and liver.EXCLI journal · 2026Review
- Reframing glucolipid metabolic disorders through the lens of the oral microbiome: from pathophysiological mechanisms to translational potential.Frontiers in nutrition · 2026Review
- Impact of Passive Solar Drying and Storage on Secondary Plant Metabolites and Nitrate Contents of Abyssinian Mustard, Amaranth, and Pumpkin Leaves.Journal of food science · 2026Article
- Editorial: Nutrition and oral microbiology: integrative perspectives for improved oral health.Frontiers in oral health · 2026Article
- Comparative genomic analysis of hydrogen peroxide and nitric oxide metabolic pathways in Limosilactobacillus fermentum.Scientific reports · 2025Article
- Influence of orthodontic appliances and nitrate on the oral microbiota.Applied microbiology and biotechnology · 2025Article
- Oral microbiome contributions to metabolic syndrome pathogenesis.Frontiers in microbiology · 2025Review
- TheFrontiers in cellular and infection microbiology · 2025Article
- Salivary Nitrate Level and Lipid Profile in Patients with Hypertension: A Cross-Sectional Study in a Saudi Sub-Population.Journal of clinical medicine · 2024Article
- Nitrate, Nitrite, and Iodine Concentrations in Commercial Edible Algae: An Observational Study.Foods (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGreen leafy vegetables (GLV) contain inorganic nitrate, an anion with potential prebiotic effects on the oral microbiome. However, it remains unclear whether GLV and pharmacological supplementation [potassium nitrate (PN)] with a nitrate salt induce similar effects on the oral microbiome.
objectivesThis study aimed to compare the effect of GLV with PN supplementation on the oral microbiome composition and salivary biomarkers in individuals with high blood pressure.
methodsSeventy individuals were randomly allocated to 3 different groups to follow a 5-wk dietary intervention. Group 1 consumed 300 mg/d of nitrate in form of GLV. Group 2 consumed pills with 300 mg/d of PN and low-nitrate vegetables. Group 3 consumed pills with potassium chloride (placebo: PLAC) and low-nitrate vegetables. The oral microbiome composition and salivary biomarkers of oral health were analyzed before and after the dietary intervention.
resultsThe GLV and PN groups showed similar microbial changes, probably nitrate-dependent, including an increase in the abundance of Neisseria, Capnocytophaga, Campylobacter species, and a decrease in Veillonella, Megasphaera, Actinomyces, and Eubacterium species after the treatment. Increased abundance of Rothia species, and reduced abundance of Streptococcus, Prevotella, Actinomyces, and Mogibacterium species were observed in the GLV group, which could be nitrate-independent. GLV and PN treatments increased salivary pH, but only GLV treatment showed an increase in the salivary buffering capacity and a reduction of lactate.
conclusionThe combination of nitrate-dependent and nitrate-independent microbial changes in the GLV group has a stronger effect to potentially improve oral health biomarkers compared with PN.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.