Evidence map›Paper›PMID 39018515›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2024

Tailored Dose-Dense Versus Standard Adjuvant Chemotherapy for High-Risk Early Breast Cancer: End-of-Study Results of the Randomized PANTHER Trial.

Alexios Matikas, Volker Möbus, Richard Greil, Anne Andersson, Günther G Steger, Michael Untch, Tommy Fornander, Per Malmström, Sabine Schmatloch, Hemming Johansson and 7 more

Registry-linked trialAbstract readRandomized Controlled TrialClinical Trial, Phase IIIMulticenter Study
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00798070 (A Randomised Phase 3 Study Comparing Biweekly and Tailored Epirubicin + Cyclophosphamide Followed by Biweekly Tailored Docetaxel Versus Three Weekly Epirubicin + Cyclophosphamide + 5-fluorouracil Followed by Docetaxel in Lymph Node Positive or High Risk Lymph Node Negative Breast Cancer Patients), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00798070 phase3active not recruitingnot on this map

A Randomised Phase 3 Study Comparing Biweekly and Tailored Epirubicin + Cyclophosphamide Followed by Biweekly Tailored Docetaxel Versus Three Weekly Epirubicin + Cyclophosphamide + 5-fluorouracil Followed by Docetaxel in Lymph Node Positive or High Risk Lymph Node Negative Breast Cancer Patients

TypeinterventionalSponsorKarolinska University HospitalRan2007 to 2028Enrolled2,017ConditionsBreast CancerArmsdtEC→dtT, FEC→T
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Review
  3. Mapping supportive-care evidence for febrile neutropenia prevention in breast cancer chemotherapy: a bibliometric analysis of long-acting G-CSF prophylaxis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  4. Article
  5. Article
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  7. Article
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  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Alexios MatikasOncology/Pathology Department, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-4122-9624
Volker MöbusDepartment of Medicine II, Hematology & Oncology, University of Frankfurt, Frankfurt, Germany.
Richard Greil3rd Medical Department, Paracelsus Medical University and Salzburg Cancer Research Institute, Cancer Cluster Salzburg and AGMT, Salzburg, Austria.ORCID 0000-0002-4462-3694
Anne AnderssonDepartment of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.ORCID 0000-0002-9597-6465
Günther G StegerDepartment of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
Michael UntchHelios Klinikum Berlin-Buch, Berlin, Germany.ORCID 0000-0002-1233-1267
Tommy FornanderOncology/Pathology Department, Karolinska Institutet, Stockholm, Sweden.
Per MalmströmDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Sabine SchmatlochElisabeth Hospital, Kassel, Germany.
Hemming JohanssonOncology/Pathology Department, Karolinska Institutet, Stockholm, Sweden.
Mats HellströmBreast Center, Karolinska Comprehensive Cancer Center, Stockholm, Sweden.ORCID 0000-0001-7897-4006
Yvonne BrandbergOncology/Pathology Department, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-9840-9266
Michael GnantComprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-1002-2118
Sibylle LoiblGerman Breast Group, Neu-Isenburg, Germany.ORCID 0000-0001-6488-4958
Theodoros FoukakisOncology/Pathology Department, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-8952-9987
Jonas BerghOncology/Pathology Department, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-5526-1847
SweBCG, ABCSG and GBG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsCyclophosphamideDocetaxelEpirubicinAdultAgedChemotherapy, AdjuvantDisease-Free SurvivalDrug Administration ScheduleFemaleHumansMiddle AgedCyclophosphamideDocetaxelEpirubicin

Identifiers

PMID39018515
PMCPMC11379357

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.