Evidence map›Paper›PMID 39018414›Full record

ArticleScience advances2024

Repression of mRNA translation initiation by GIGYF1 via disrupting the eIF3-eIF4G1 interaction.

Jung-Hyun Choi, Jun Luo, Geoffrey G Hesketh, Shuyue Guo, Angelos Pistofidis, Reese Jalal Ladak, Yuxin An, Parisa Naeli, Tommy Alain, T Martin Schmeing and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. The 4EHP-mediated translational repression of cGAS impedes the host immune response against DNA viruses.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jung-Hyun ChoiRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada.ORCID 0000-0002-8992-4992
Jun LuoRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada.ORCID 0000-0002-3177-0839
Geoffrey G HeskethDepartment of Biochemistry & Molecular Biology, Dalhousie University, Halifax, NS, Canada.ORCID 0000-0002-5570-7615
Shuyue GuoRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada.
Angelos PistofidisDepartment of Biochemistry, McGill University, Montreal, QC H3A 1A3, Canada.
Reese Jalal LadakRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada.
Yuxin AnRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada.
Parisa NaeliPatrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast BT9 7AE, UK.
Tommy AlainDepartment of Biochemistry, Microbiology and Immunology, Children's Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, ON, Canada.ORCID 0000-0002-0396-9138
T Martin SchmeingDepartment of Biochemistry, McGill University, Montreal, QC H3A 1A3, Canada.ORCID 0000-0002-8061-0436
Anne-Claude GingrasCentre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada.ORCID 0000-0002-6090-4437
Thomas DuchaineRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada.
Xu ZhangRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada.ORCID 0000-0002-2440-2552
Nahum SonenbergRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada.ORCID 0000-0002-4707-8759
Seyed Mehdi JafarnejadPatrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast BT9 7AE, UK.ORCID 0000-0002-5129-7081

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viruses can selectively repress the translation of mRNAs involved in the antiviral response. RNA viruses exploit the Grb10-interacting GYF (glycine-tyrosine-phenylalanine) proteins 2 (GIGYF2) and eukaryotic translation initiation factor 4E (eIF4E) homologous protein 4EHP to selectively repress the translation of transcripts such as

Indexed as

Eukaryotic Initiation Factor-3Eukaryotic Initiation Factor-4GProtein BindingRNA, MessengerAnimalsCarrier ProteinsGene Expression RegulationHumansInterferon-betaPeptide Chain Initiation, TranslationalProtein BiosynthesisCarrier ProteinsEIF4G1 protein, humanEukaryotic Initiation Factor-3Eukaryotic Initiation Factor-4GGIGYF2 protein, humanInterferon-betaRNA, Messenger

Identifiers

PMID39018414
PMCPMC466957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.