Evidence map›Paper›PMID 39017881›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2024

Using Ex Vivo Tonsil Organoids to Study Memory B Cells.

Zachary W Wagoner, Mahina Tabassum Mitul, Lisa E Wagar

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Frontiers in cellular and infection microbiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zachary W WagonerDepartment of Physiology and Biophysics, Institute for Immunology, Center for Virus Research, and Vaccine R&D Center, University of California Irvine, Irvine, CA, USA.
Mahina Tabassum MitulDepartment of Physiology and Biophysics, Institute for Immunology, Center for Virus Research, and Vaccine R&D Center, University of California Irvine, Irvine, CA, USA.
Lisa E WagarDepartment of Physiology and Biophysics, Institute for Immunology, Center for Virus Research, and Vaccine R&D Center, University of California Irvine, Irvine, CA, USA. lwagar@hs.uci.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tools to study memory B cell (MBC) development and function are needed to understand their role in supporting sustained protection against recurrent infections. While human MBCs are traditionally measured using blood, there is a growing interest in elucidating their behavior within lymphoid tissues, which are the main sites where adaptive immune responses are orchestrated. In this chapter, we introduce a high-throughput organoid system that is derived from primary human lymphoid tissues. The approach can recapitulate many hallmarks of successful adaptive immune responses and capture inter-individual variation in response to a variety of stimuli. Lymphoid tissue organoids enable characterization of pre-existing antigen-specific MBCs within an entirely human system and can provide valuable insights into MBC dynamics.

Indexed as

B-LymphocytesImmunologic MemoryOrganoidsPalatine TonsilCell Culture TechniquesCells, CulturedHumansAntigen-specific B cellsHuman immunologyImmune organoidsLymphoid tissueVaccine response

Identifiers

PMID39017881

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.