Evidence map›Paper›PMID 39017841›Full record

ReviewAdvances in experimental medicine and biology2024

The Function of E2A in B-Cell Development.

Masaki Miyazaki, Kazuko Miyazaki

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Masaki MiyazakiLaboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan. mmiyazaki@infront.kyoto-u.ac.jp.
Kazuko MiyazakiLaboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Helix-loop-helix (HLH) transcription factors (TFs) play a key role in various cellular differentiation and function through the regulation of enhancer activity. E2A, a member of the mammalian E-protein family (class I HLH protein), is well known to play an important role in hematopoiesis, especially in adaptive lymphocyte development. E2A instructs B- and T-cell lineage development through the regulation of enhancer activity for B- or T-cell signature gene expression, including Rag1 and Rag2 (Rag1/2) genes. In this chapter, we mainly focus on the function of E2A in B-cell development and on the roles of E2A in establishing the enhancer landscape through the recruitment of EP300/KAT3B, chromatin remodeling complex, mediator, cohesion, and TET proteins. Finally, we demonstrate how E2A orchestrates the assembly of the Rag1/2 gene super-enhancer (SE) formation by changing the chromatin conformation across the Rag gene locus.

Indexed as

B-LymphocytesHomeodomain ProteinsAnimalsBasic Helix-Loop-Helix ProteinsCell DifferentiationChromatinChromatin Assembly and DisassemblyDNA-Binding ProteinsE1A-Associated p300 ProteinEnhancer Elements, GeneticHumansNuclear ProteinsBasic Helix-Loop-Helix ProteinsChromatinDNA-Binding ProteinsE1A-Associated p300 ProteinHomeodomain ProteinsNuclear ProteinsRAG-1 proteinRAG2 protein, humanTCF3 protein, humanAdaptive lymphocyteBasic-helix-loop-helix transcription factorB-cell developmentE2AEnhancer regulationRag1 and Rag2 expression

Identifiers

PMID39017841

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.