Evidence map›Paper›PMID 39017743›Full record

ArticlePediatric surgery international2024

Systemic inflammation enhances metastatic growth in a syngeneic neuroblastoma mouse model.

Kazuya Mimura, Shigehisa Fumino, Kodai Yamashi, Masafumi Iguchi, Maho Inoue, Shohei Takayama, Kiyokazu Kim, Shigeyoshi Aoi, Tatsuro Tajiri, Shigeru Ono

Abstract read
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Article in Pediatric surgery international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kazuya MimuraDepartment of Pediatric Surgery, Kyoto Prefectural University of Medicine, 465 Kajii Cho, Kawaramachi Hirokoji, Kamigyo Ku, Kyoto, 602-8566, Japan. kazuyam@koto.kpu-m.ac.jp.
Shigehisa FuminoDepartment of Pediatric Surgery, Kyoto Prefectural University of Medicine, 465 Kajii Cho, Kawaramachi Hirokoji, Kamigyo Ku, Kyoto, 602-8566, Japan.
Kodai YamashiDepartment of Pediatric Surgery, Kyoto Prefectural University of Medicine, 465 Kajii Cho, Kawaramachi Hirokoji, Kamigyo Ku, Kyoto, 602-8566, Japan.
Masafumi IguchiDepartment of Pediatric Surgery, Kyoto Prefectural University of Medicine, 465 Kajii Cho, Kawaramachi Hirokoji, Kamigyo Ku, Kyoto, 602-8566, Japan.
Maho InoueDepartment of Pediatric Surgery, Kyoto Prefectural University of Medicine, 465 Kajii Cho, Kawaramachi Hirokoji, Kamigyo Ku, Kyoto, 602-8566, Japan.
Shohei TakayamaDepartment of Pediatric Surgery, Kyoto Prefectural University of Medicine, 465 Kajii Cho, Kawaramachi Hirokoji, Kamigyo Ku, Kyoto, 602-8566, Japan.
Kiyokazu KimDepartment of Pediatric Surgery, Kyoto Prefectural University of Medicine, 465 Kajii Cho, Kawaramachi Hirokoji, Kamigyo Ku, Kyoto, 602-8566, Japan.
Shigeyoshi AoiDepartment of Pediatric Surgery, Kyoto Prefectural University of Medicine, 465 Kajii Cho, Kawaramachi Hirokoji, Kamigyo Ku, Kyoto, 602-8566, Japan.
Tatsuro TajiriDepartment of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Shigeru OnoDepartment of Pediatric Surgery, Kyoto Prefectural University of Medicine, 465 Kajii Cho, Kawaramachi Hirokoji, Kamigyo Ku, Kyoto, 602-8566, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe previously showed that total tumor resection enhances metastatic growth in a syngeneic metastatic mouse model of neuroblastoma. In this study, we further investigated which surgical factors contributed most to metastatic growth.

methodsTumor cells derived from MYCN transgenic mice were subcutaneously injected into wild-type mice. Mice were randomly assigned to receive partial resection (PR group), subcutaneous implantation of a sponge (Sp group), or observation (Obs group). The lymph node metastasis volume and the frequency of lung metastasis were compared 14 days after assignment by measuring C-reactive protein (CRP) and interleukin-6 (IL-6) levels.

resultsThe lymph node metastasis volume in the Sp group was larger than in the Obs group (148.4 [standard deviation {SD}: 209.5] vs. 10.2 [SD 12.8] mm

conclusionMetastatic growth may be enhanced by systemic inflammation.

Indexed as

C-Reactive ProteinDisease Models, AnimalInflammationLung NeoplasmsNeuroblastomaAnimalsInterleukin-6Lymphatic MetastasisMiceMice, TransgenicC-Reactive ProteinInterleukin-6MetastasisMYCN transgenic mouseNeuroblastomaSurgical inflammationSyngeneic mouse model

Identifiers

PMID39017743

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.