Evidence map›Paper›PMID 39017683›Full record

ArticleDiabetes care2024

Association Between Accelerometer-Measured Irregular Sleep Duration and Type 2 Diabetes Risk: A Prospective Cohort Study in the UK Biobank.

Sina Kianersi, Heming Wang, Tamar Sofer, Raymond Noordam, Andrew Phillips, Martin K Rutter, Susan Redline, Tianyi Huang

Abstract read
In one paragraph

Article in Diabetes care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
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  4. Review
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  7. Fluctuations in Sleep Duration and Timing and Cardiometabolic Risk.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Accelerometer-measured weekend catch-up sleep and incident dementia: A prospective cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sina KianersiChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.ORCID 0000-0003-0950-2675
Heming WangDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Tamar SoferDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Raymond NoordamDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Andrew PhillipsTurner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia.
Martin K RutterDivision of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, University of Manchester, Manchester, U.K.
Susan RedlineDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Tianyi HuangChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.ORCID 0000-0001-8420-9167

Funding

The role of irregular sleep schedules as a ubiquitous marker of chronic circadian disruption in cardiometabolic disease developmentR01HL155395 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2021 to 2025
$3.5M
Dissecting heterogeneity of excessive daytime sleepiness and impact on cardiovascular diseasesR01HL153814 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WANG, HEMING · 2021 to 2025
$2.0M
Multi-Dimensional Sleep Health and Aging-Related Chronic Disease RiskZIAAG000530 · NIA · NATIONAL INSTITUTE ON AGING · PI HUANG, TIANYI · 2024 to 2025
$539k
American Heart Association 24POST1188091NHLBI NIH HHS R01 HL153814NHLBI NIH HHS R01 HL155395NHLBI NIH HHS R01HL155395
6 · The paper itself

Abstract

objectiveTo evaluate the association between irregular sleep duration and incident diabetes in a U.K. population over 7 years of follow-up. RESEARCH DESIGN AND

methodsAmong 84,421 UK Biobank participants (mean age 62 years) who were free of diabetes at the time of providing accelerometer data in 2013-2015 and prospectively followed until May 2022, sleep duration variability was quantified by the within-person SD of 7-night accelerometer-measured sleep duration. We used Cox proportional hazard models to estimate hazard ratios (HRs) for incident diabetes (identified from medical records, death register, and/or self-reported diagnosis) according to categories of sleep duration SD.

resultsThere were 2,058 incident diabetes cases over 622,080 person-years of follow-up. Compared with sleep duration SD ≤ 30 min, the HR (95% CI) was 1.15 (0.99, 1.33) for 31-45 min, 1.28 (1.10, 1.48) for 46-60 min, 1.54 (1.32, 1.80) for 61-90 min, and 1.59 (1.33, 1.90) for ≥91 min, after adjusting for age, sex, and race. We found a nonlinear relationship (P nonlinearity 0.0002), with individuals with a sleep duration SD of >60 vs. ≤60 min having 34% higher diabetes risk (95% CI 1.22, 1.47). Further adjustment for lifestyle, comorbidities, environmental factors, and adiposity attenuated the association (HR comparing sleep duration SD of >60 vs. ≤60 min: 1.11; 95% CI 1.01, 1.22). The association was stronger among individuals with lower diabetes polygenic risk score (PRS; P interaction ≤ 0.0264) and longer sleep duration (P interaction ≤ 0.0009).

conclusionsIrregular sleep duration was associated with higher diabetes risk, particularly in individuals with a lower diabetes PRS and longer sleep duration.

Indexed as

AccelerometryBiological Specimen BanksDiabetes Mellitus, Type 2SleepAgedFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsSleep DurationUK BiobankUnited Kingdom

Identifiers

PMID39017683
PMCPMC11362127

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.