Evidence map›Paper›PMID 39016592›Full record

ArticleAntimicrobial agents and chemotherapy2024

Efficacy of epetraborole against

Binayak Rimal, Christopher K Lippincott, Chandra M Panthi, Yi Xie, Tiffany R Keepers, Mrk Alley, Gyanu Lamichhane

Registry-linked trialAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07301320 (A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Prospective, Investigator-Initiated Trial to Assess the Efficacy, Safety, and Pharmacokinetics of Epetraborole in Patients With Mycobacterium Abscessus Lung Disease), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07301320 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Prospective, Investigator-Initiated Trial to Assess the Efficacy, Safety, and Pharmacokinetics of Epetraborole in Patients With Mycobacterium Abscessus Lung Disease: REBOUND Study

TypeinterventionalSponsorKevin WinthropRan2026 to 2028Enrolled84ConditionsMycobacterium Abscessus InfectionArmsEpetraborole, Placebo
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. CRISPRi-mediatedAntimicrobial agents and chemotherapy · 2026
    Article
  2. Article
  3. Article
  4. CRISPRi-mediated validation of candidatebioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Review
  7. Toward better cures forClinical microbiology reviews · 2024
    Review
  8. Article
  9. Oral oxaborole MRX-5 exhibits efficacy against pulmonaryAntimicrobial agents and chemotherapy · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Binayak RimalDivision of Infectious Diseases, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Christopher K LippincottDivision of Infectious Diseases, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Chandra M PanthiDivision of Infectious Diseases, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Yi XieDivision of Infectious Diseases, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Tiffany R KeepersAN2 Therapeutics, Inc., Menlo Park, California, USA.
Mrk AlleyAN2 Therapeutics, Inc., Menlo Park, California, USA.
Gyanu LamichhaneDivision of Infectious Diseases, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-2214-0114

Funding

A strategy for new regimens to treat pulmonary Mycobacteroides abscessus infectionR01AI155664 · NIAID · JOHNS HOPKINS UNIVERSITY · PI LAMICHHANE, GYANU · 2020 to 2024
$2.1M
AN2 Therapeutics IncHHS | National Institutes of Health (NIH) NIH AI155664NIAID NIH HHS R01 AI155664
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Bacterial AgentsDisease Models, AnimalMycobacterium abscessusMycobacterium Infections, NontuberculousAnimalsFemaleLungMiceMicrobial Sensitivity TestsAnti-Bacterial AgentsepetraboroleMycobacterium abscessus

Identifiers

PMID39016592
PMCPMC11323969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.