ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Sustained frailty remission and dementia risk in older adults: A longitudinal study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Real experiences and care needs of frail older patients: a systematic review of qualitative studies.Frontiers in public health · 2025Pooled it
- Joint trajectories of sleep deviation risk and frailty and their associations with cognitive decline in middle-aged and older adults: a population-based cohort study.BMC public health · 2026Article
- Dual trajectories of intrinsic capacity and frailty: a joint predictor framework for dementia risk in middle-aged and older adults.BMC public health · 2026Article
- The application value of frailty assessment tools in the perioperative period: A narrative review.Journal of anesthesia and translational medicine · 2026Review
- Gender differences in the association between physical frailty and cognitive function among older adults: A cross-sectional study in rural Guizhou, China.Scientific reports · 2026Article
- Clinical Trajectories of Neurodegenerative Diseases in Older Adults: A Three-Sphere Framework for Precision Geriatric Neurology.Life (Basel, Switzerland) · 2026Article
- Estimated Cardiorespiratory Fitness and Risk of Incident Frailty in Middle-Aged and Older Adults: A Cross-National Longitudinal Cohort Study.Healthcare (Basel, Switzerland) · 2026Article
- Association of transitions in frailty with dementia risk: findings from two longitudinal cohort studies.Frontiers in medicine · 2026Article
- Nonagenarians with major neurocognitive disorder hospitalized in a high-complexity hospital.Dementia & neuropsychologia · 2026Article
- Impact of Caregiver Burden and Care Recipients' Activities of Daily Living Abilities on Caregivers' Occupational Dysfunction.Occupational therapy international · 2026Article
- Associations of changes in frailty with multiple chronic diseases in middle aged and elderly adults.BMC public health · 2025Article
- Microglia in Brain Aging and Age-Related Diseases: Friends or Foes?International journal of molecular sciences · 2025Review
- Exploring Frailty Status and Blood Biomarkers: A Multidimensional Approach to Alzheimer's Diagnosis.Geriatrics (Basel, Switzerland) · 2025Article
- Sustained frailty remission and future cardiovascular disease risk: a longitudinal study from the UK Biobank.Archives of public health = Archives belges de sante publique · 2025Article
- The Impact of Frailty, Activity of Daily Living, and Malnutrition on Mortality in Older Adults with Cognitive Impairment and Dementia.Nutrients · 2025Article
- Exposure to the Chinese famine during early life increases the risk of frailty in adulthood: Evidence from the China Health and Retirement Longitudinal Study.Preventive medicine reports · 2025Article
- Article
- The Frailty, Fitness, and Psychophysical/Social Condition of Community-Dwelling Older Adults-Analysis of 5-Year Longitudinal Data.Geriatrics (Basel, Switzerland) · 2025Article
- Multitrajectories of Frailty and Depression With Cognitive Function: Findings From the Health and Retirement Longitudinal Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Associations of estimated glucose disposal rate with frailty progression: results from two prospective cohorts.Cardiovascular diabetology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionPhysical frailty is reversible, but little is known about the sustainability of frailty remission and its impact on dementia.
methodsData were derived from the National Health and Aging Trends Study (NHATS) (2011 to 2021). Physical frailty was assessed using the Fried frailty phenotype, and frailty transition patterns across three waves were defined. The relationship of sustained frailty remission with incident dementia was examined using Cox proportional regression, stratified by age and gender.
resultsAmong 1931 participants, 348 (18.0%) were capable of sustained frailty remission. During the 8-year follow-up, 279 participants developed dementia. In a fully adjusted model, sustained remission was associated with a lower risk of dementia (hazard ratio = 0.66, 95% confidence interval = 0.47 to 0.93). The association was more pronounced among younger-old and male participants but not observed among their counterparts. DISCUSSION: Sustained frailty remission was associated with a reduced risk of developing dementia. Physical frailty could be an essential forewarning of dementia and a target for interventions. HIGHLIGHTS: We provided new insights into the natural progression of frailty and its impact on dementia risk using a nationally representative sample Sustained frailty remission reduced risk of incident dementia. Age and gender played a role in the frailty-dementia link, and thus individualized dementia risk screening is necessary. Physical frailty could be an essential forewarning of cognitive decline and an ideal target for interventions to prevent dementia.
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