ArticleArquivos brasileiros de cardiologia2024
Inflammation Burden and Atrial Fibrillation Burden: A Bidirectional Relationship.
Article in Arquivos brasileiros de cardiologia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Atrial Fibrillation Recurrence Reduction: What Treatments Work Best Postablation? A Network Meta-Analysis.Journal of cardiovascular electrophysiology · 2025Pooled it
- The Relationship Between Atrial Fibrillation and the Systemic Immune Inflammation Index in Well-Controlled Hypertensive Patients with Newly Developed Atrial Fibrillation.Journal of clinical medicine · 2026Article
- Exploring the relationship between uric acid-to-HDL cholesterol ratio and vascular calcification: evidence from clinical, genetic, and network-based analyses.Frontiers in cardiovascular medicine · 2026Article
- The role of periodontitis as a modifier of diabetes mellitus in older patients with atrial fibrillation.BMC endocrine disorders · 2025Observational
- Inflammatory Burden Index Associated with Recurrence of Atrial Fibrillation After Radiofrequency Catheter Ablation.Therapeutics and clinical risk management · 2025Article
- Role of a new inflammation predictor in predicting recurrence of atrial fibrillation after radiofrequency catheter ablation.World journal of cardiology · 2024Article
- Inflammation and Atrial Fibrillation: An Exclusive Association or an Accomplice to the Cardiovascular Continuum of Additional Risk Factors?Arquivos brasileiros de cardiologia · 2024Article
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8 authors.
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Abstract
backgroundAtrial fibrillation (AF) burden is defined as the proportion of time the patient remains in AF over a given period of time; thus, it is theoretically highest in permanent AF and lowest in paroxysmal AF. Inflammation is associated with the initiation and maintenance of AF. However, the relationship between systemic immune-inflammation index (SII) and AF burden is unknown.
objectiveIn the present study, we investigated the relationship between SII and AF burden.
methodsThe present study is a cross-sectional analysis of 453 patients (252 females and 201 males, aged 44 to 94 years) with AF (138 with paroxysmal AF and 315 with permanent AF) who visited the cardiology outpatient clinic between October 2022 and June 2023. SII was calculated as (neutrophils × platelets/lymphocytes). The predictive role of SII and other inflammatory markers in the likelihood of AF pattern was evaluated by logistic regression analyses, and p value < 0.05 was considered statistically significant.
resultsAge, diastolic blood pressure, heart rate, diabetes mellitus, neutrophil, platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, SII, C-reactive protein, red blood cell distribution width, hemoglobin A1c, and left atrial diameter were significantly higher in the permanent AF group. According to the logistic regression analysis, age (p = 0.038), diabetes mellitus (p = 0.024), red blood cell distribution width (p = 0.023), C-reactive protein (p = 0.010), SII (p = 0.001), and left atrial diameter (p < 0.001) significantly contributed to the prediction of the likelihood of permanent AF.
conclusionSII is independently associated with the AF burden. Prospective studies are needed to determine whether SII may be useful in identifying patients at high risk for AF progression.
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