Evidence map›Paper›PMID 39016354›Full record

SynthesisActa obstetricia et gynecologica Scandinavica2024

Association between human papillomavirus and preterm delivery: A systematic review and meta-analysis.

Dénes Kovács, Anett Szabó, Péter Hegyi, Nándor Ács, Márton Keszthelyi, Levente Sára, Ádám Csirzó, Péter Mátrai, Krisztina Munnoch, Rita Nagy and 1 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Acta obstetricia et gynecologica Scandinavica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dénes KovácsDepartment of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.ORCID 0000-0001-7994-3340
Anett SzabóCenter for Translational Medicine, Semmelweis University, Budapest, Hungary.
Péter HegyiInstitute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
Nándor ÁcsDepartment of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.ORCID 0000-0002-1919-1869
Márton KeszthelyiDepartment of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
Levente SáraDepartment of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
Ádám CsirzóDepartment of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
Péter MátraiInstitute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
Krisztina MunnochCenter for Translational Medicine, Semmelweis University, Budapest, Hungary.
Rita NagyCenter for Translational Medicine, Semmelweis University, Budapest, Hungary.
Ferenc BánhidyDepartment of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe lifetime prevalence of human papillomavirus infection (HPV) is estimated to be around 80% and it is the most common sexually transmitted infection. Despite being well known for its oncologic relevance, it has been associated with adverse pregnancy outcomes, though available evidence is contradicting. Previous meta-analyses involved articles which based HPV infection on Pap smear results, leading to a significant source of bias. Therefore, we aimed to assess the burden of genetically proven HPV infection on adverse pregnancy outcomes. MATERIAL AND

methodsIn our meta-analysis, pregnant women tested for HPV DNA were only considered eligible. We conducted a systematic search in three major databases (PubMed, Embase, and CENTRAL) on September 22, 2023. Cohort, cross-sectional, and case-control studies were eligible for the analysis. The exposed group consisted of HPV-infected patients. We assessed the odds ratios (OR) with a confidence interval (CI) of 95%. In order to reduce the heterogeneity, we performed subgroup analyses based on different strains (high risk HPV, HPV 16/18, study design). The study was prospectively registered on PROSPERO (CRD42022370228).

resultsOur study involved 14 articles with 7008 women. A significant association was found between preterm delivery and HPV infection (OR: 1.94, CI: 1.31-2.87). No significant association was found when separately examining high-risk HPV-infected women (OR: 1.94, CI: 0.82-4.59), and HPV 16 or 18-infected women (OR: 2.08, CI: 0.50-8.63) in terms of preterm delivery. No significant association was found between spontaneous abortion and HPV infection (OR: 1.02, CI: 0.16-6.31).

conclusionsOur analysis indicates an association between HPV infection and preterm delivery. It is imperative that future studies consider confounding variables more comprehensively. Additionally, the global implementation of HPV vaccination programs holds significance not only in oncology but also in obstetrics.

Indexed as

Papillomavirus InfectionsPremature BirthFemaleHuman Papillomavirus VirusesHumansPapillomaviridaePregnancyPregnancy Complications, InfectiousHPV infectionpregnancypregnancy losspreterm birthsexually transmitted infection

Identifiers

PMID39016354
PMCPMC11426213

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.