Evidence map›Paper›PMID 39016172›Full record

ReviewHuman vaccines & immunotherapeutics2024

Public health management of pertussis in adults: Practical challenges and future strategies.

C Raina MacIntyre, Jaime Correia de Sousa, Ulrich Heininger, Peter Kardos, Andreas Konstantopoulos, Donald Middleton, Terry Nolan, Alberto Papi, Adrian Rendon, Albert Rizzo and 8 more

Abstract readReview
In one paragraph

Review in Human vaccines & immunotherapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Review
  7. Article
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  9. Review
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  12. Resurgence of pertussis: whopping the '100-day cough'.Current opinion in pediatrics · 2025
    Review
  13. Review
  14. Article
  15. The 2024 resurgence ofFrontiers in public health · 2025
    Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

C Raina MacIntyreKirby Institute, University of New South Wales, Sydney, Australia.ORCID 0000-0002-3060-0555
Jaime Correia de SousaSchool of Medicine, University of Minho, Braga, Portugal.
Ulrich HeiningerChildren's Hospital, University of Basel, Basel, Switzerland.
Peter KardosGroup Practice & Center, Allergy, Respiratory and Sleep Medicine, Maingau Hospital of The Red Cross, Frankfurt am Main, Germany.
Andreas KonstantopoulosDepartment of Pediatrics, University of Athens, Athens, Greece.
Donald MiddletonDepartment of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Terry NolanVaccine and Immunisation Research Group, Murdoch Childrens Research Institute and Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
Alberto PapiDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.
Adrian RendonUniversidad Autonoma de Nuevo Leon, Hospital Universitario "Dr. Jose Eleuterio Gonzalez", CIPTIR, Monterrey, Mexico.
Albert RizzoAmerican Lung Association, Chicago, IL, USA.
Kim SampsonImmunisation Coalition, Melbourne, Australia.
Alessandro SetteCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, San Diego, California USA.
Elizabeth SobczykAMDA - The Society for Post-Acute and Long-Term Care Medicine, Columbia, SC, USA.
Tina TanFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Catherine Weil-OlivierHonorary Professor of Pediatrics, University of Paris, Paris, France.
Birgit WeinbergerInstitute for Biomedical Aging Research, Universität Innsbruck, Innsbruck, Austria.
Tom WilkinsonFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.
Carl Heinz Wirsing von KönigClinical Microbiology Consultant, Das Labor: Medizin Krefeld MVZ, Krefeld, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A panel of 24 international experts met in July 2022 to discuss challenges associated with pertussis detection, monitoring, and vaccination in adults; conclusions from this meeting are presented. There has been a shift in the epidemiology of pertussis toward older children and adults. This shift has been attributed to the waning of infection- or vaccine-induced immunity, newer detection techniques causing detection bias, and possibly the replacement of whole-cell pertussis with acellular vaccines in high-income countries, which may lead to immunity waning more quickly. The burden of adult pertussis is still likely under-ascertained due to widespread under-recognition by healthcare professionals (HCPs), under-diagnosis, and under-reporting in this age group. Non-standardized testing guidance and varied case definitions have contributed to under-reporting. Key barriers to HCP engagement with the tetanus, diphtheria, and pertussis (Tdap) vaccine include low awareness, lack of time/funding, and lack of motivation due to low prioritization of Tdap.

Indexed as

VaccinationWhooping CoughAdultDiphtheria-Tetanus-acellular Pertussis VaccinesHumansPertussis VaccinePublic HealthPublic Health AdministrationDiphtheria-Tetanus-acellular Pertussis VaccinesPertussis VaccineadultsBordetella pertussiscomorbiditiesdisease burdenTdap vaccinationunder-reporting

Identifiers

PMID39016172
PMCPMC11259069

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.