Evidence map›Paper›PMID 39016119›Full record

ArticlePhysiological reports2024

Analysis of alpha-1-antitrypsin (AAT)-regulated, glucocorticoid receptor-dependent genes in macrophages reveals a novel host defense function of AAT.

Xiyuan Bai, Junfeng Gao, Xiaoyu Guan, Drew E Narum, Lorelenn B Fornis, David E Griffith, Bifeng Gao, Robert A Sandhaus, Hua Huang, Edward D Chan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiyuan BaiDepartment of Medicine, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colorado, USA.
Junfeng GaoDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado, USA.
Xiaoyu GuanDepartment of Biostatistics and Informatics, University of Colorado School of Public Health Anschutz Medical Campus, Aurora, Colorado, USA.
Drew E NarumDepartment of Academic Affairs, National Jewish Health, Denver, Colorado, USA.
Lorelenn B FornisDepartment of Academic Affairs, National Jewish Health, Denver, Colorado, USA.
David E GriffithDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Bifeng GaoDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Robert A SandhausDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Hua HuangDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado, USA.
Edward D ChanDepartment of Medicine, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colorado, USA.ORCID 0000-0001-7612-7727

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Cancer Center Support Grant P30CA046934NCI NIH HHS P30 CA046934
6 · The paper itself

Abstract

Alpha-1-antitrypsin (AAT) plays a homeostatic role in attenuating excessive inflammation and augmenting host defense against microbes. We demonstrated previously that AAT binds to the glucocorticoid receptor (GR) resulting in significant anti-inflammatory and antimycobacterial consequences in macrophages. Our current investigation aims to uncover AAT-regulated genes that rely on GR in macrophages. We incubated control THP-1 cells (THP-1

Indexed as

alpha 1-AntitrypsinMacrophagesReceptors, GlucocorticoidGene Expression RegulationGranulocyte-Macrophage Colony-Stimulating FactorHumansTHP-1 Cellsalpha 1-AntitrypsinGranulocyte-Macrophage Colony-Stimulating FactorReceptors, GlucocorticoidSERPINA1 protein, humanAATgene regulationglucocorticoid receptorGM‐CSFserine protease

Identifiers

PMID39016119
PMCPMC11252833

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.