Evidence map›Paper›PMID 39016077›Full record

Trial reportClinical and experimental dental research2024

Evaluation of the Effects of Punica granatum Flower Tablets on Pain and Healing of Minor Recurrent Aphthous Stomatitis: A Randomized Clinical Trial.

Fatemeh Lavaee, Elahehnaz Parhizkar, Fatemeh Tavakoli, Mohammad M Zarshenas, Naeimehossadat Asmarian

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Clinical and experimental dental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fatemeh LavaeeOral and Maxillofacial Disease Department, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID 0000-0001-8896-1225
Elahehnaz ParhizkarDepartment of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID 0000-0002-6372-9611
Fatemeh TavakoliOral and Maxillofacial Medicine Department, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID 0000-0002-3297-5465
Mohammad M ZarshenasDepartment of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID 0000-0002-8185-4993
Naeimehossadat AsmarianAnesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Funding

This study was funded by the Vice-Chancellor of Shiraz University of Medical Science (Grant number: 21846).
6 · The paper itself

Abstract

objectivesThe purpose of this study was to determine the therapeutic effect of the Punica granatum (PG) flower on recurrent aphthous stomatitis in comparison with corticosteroid therapy. MATERIALS AND

methodsThis cross-over randomized clinical trial was conducted on the patients who had been referred to Shiraz Dental School for their RAS in 2021. All the participants used both P. granatum flower tablets and Triadent a month apart for wash-out time and all compared themselves. In the experimental group, 30 patients received pomegranate flower tablets, three tablets daily, for 6 days. In the control group, oral paste Triadent has been prescribed three times a day for 6 days. The visual analog scale (VAS) and the size of RAS were evaluated on Days 0-6. Data were analyzed by SPSS version 21. The Wilcoxon test was used.

resultsThe mean age of participants was 27.8 ± 14.77 years old. In this study, 15 patients (50%) were men and 15 patients (50%) were women. The mean value of VAS after using prescribed treatment in both evaluated groups on all days was significantly different such that the VAS values were lower for PG flower tablets than Triadent (p value < 0.05). The size of oral lesions in participants who used PG flower tablets was significantly less than those who used Triadent on all evaluation days (p value < 0.05) except on Day 1 (p value = 0.29). The descending slope of VAS from Days 1 to 6 for both Triadent and PG flower tablet users was significant and noticeable. (p value < 0.05).

conclusionAccording to the result of this study, both P. granatum flower tablet and Triadent are useful in reducing the size, period of healing, and VAS of patients with RAS, but the PG flower tablet is more effective.

Indexed as

Cross-Over StudiesFlowersPlant ExtractsPomegranateStomatitis, AphthousTabletsAdolescentAdultFemaleHumansMaleMiddle AgedPainPain MeasurementPhytotherapyRecurrencePlant ExtractsTabletsPunica granatum flower tabletrecurrent aphthous stomatitistriadent

Identifiers

PMID39016077
PMCPMC11252825

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.