ArticleBrain communications2024
Impaired glymphatic system in genetic frontotemporal dementia: a GENFI study.
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Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10citing papers in PubMed, 1 pooled it
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Unveiling the glymphatic system's impact on neurodegenerative diseases: a comprehensive bibliometric analysis (2012-2024).Frontiers in aging neuroscience · 2025Pooled it
- The role of glymphatic dysfunction in cerebral small vessel disease and vascular cognitive impairment, and therapeutic implications.International journal of stroke : official journal of the International Stroke Society · 2026Review
- Free water changes and their correlations with multimodal biomarkers in frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Non-invasive brain stimulation in frontotemporal dementia: syndrome-specific signals and priorities for future trials.Frontiers in aging neuroscience · 2026Review
- Retinal microvascular alterations reflect cerebral small vessel disease burden in frontotemporal dementia: a multimodal OCTA-MRI Study.Alzheimer's research & therapy · 2025Article
- A cross-tissue transcriptome-wide association study identifies novel candidate genes associated with brain glymphatic system function.Molecular brain · 2025Article
- Impaired Glymphatic Clearance, Measured Using Diffusion Tensor Image Analysis Along the Perivascular Space (DTI-ALPS), is Linked to Poor Cognitive Outcomes in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Article
- Glymphatic activity in behavioral variant frontotemporal dementia: Link with vascular function and astrocytic activation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Comprehensive and stratified meta-analysis of diffusion tensor image analysis along the perivascular space in Alzheimer's disease: Linking glymphatic dysfunction with cognitive decline and amyloid pathology.Journal of Alzheimer's disease reportsReview
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Authors and funding
42 authors.
Enrico PremiStroke Unit, ASST Spedali Civili Brescia, Brescia, 25123, Italy.
Matteo DianoDepartment of Psychology, University of Torino, Turin, 10124, Italy.
Irene MattioliDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, 25123, Italy.
Daniele AltomareDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, 25123, Italy.
Valentina CantoniDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, 25123, Italy.
Martina BocchettaDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, WC1N, UK.ORCID https://orcid.org/0000-0003-1814-5024
Roberto GasparottiNeuroradiology Unit, University of Brescia, Brescia, 25123, Italy.
Emanuele BurattiInternational Centre for Genetic Enginneering and Biotechnology, Trieste, 34149, Italy.ORCID https://orcid.org/0000-0002-1356-9074
Marta PengoDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, 25123, Italy.
Arabella BouziguesDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, WC1N, UK.
Lucy L RussellDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, WC1N, UK.
Phoebe H FosterDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, WC1N, UK.
Eve Ferry-BolderDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, WC1N, UK.
Carolin HellerDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, WC1N, UK.
John C van SwietenDepartment of Neurology, Erasmus Medical Centre, Rotterdam, 2040 3000, The Netherlands.
Lize C JiskootDepartment of Neurology, Erasmus Medical Centre, Rotterdam, 2040 3000, The Netherlands.ORCID https://orcid.org/0000-0002-1120-1858
Harro SeelaarDepartment of Neurology, Erasmus Medical Centre, Rotterdam, 2040 3000, The Netherlands.ORCID https://orcid.org/0000-0003-1989-7527
Fermin MorenoCognitive Disorders Unit, Department of Neurology, Donostia University Hospital, San Sebastian, 20014, Spain.
Raquel Sanchez-ValleAlzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Barcelona, 08036, Spain.ORCID https://orcid.org/0000-0001-7750-896X
Daniela GalimbertiFondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, 20122, Italy.
Robert LaforceClinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques, CHU de Québec, Faculté de Médecine, Université Laval, Quebec City, G1V 0A6, Canada.
Caroline GraffCenter for Alzheimer Research, Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Bioclinicum, Karolinska Institutet, Solna, 17177, Sweden.ORCID https://orcid.org/0000-0002-9949-2951
Mario MasellisSunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, ON M4N 3M5, Canada.ORCID https://orcid.org/0000-0002-6244-2096
Maria Carmela TartagliaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON M4N 3M5, Canada.
James B RoweDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 1TN, UK.
Elizabeth FingerDepartment of Clinical Neurological Sciences, University of Western Ontario, London, ON N6A 5A5, Canada.
Rik VandenbergheLaboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, 3000, Belgium.ORCID https://orcid.org/0000-0001-6237-2502
Alexandre de MendonçaFaculty of Medicine, University of Lisbon, Lisbon, 1649-004, Portugal.
Chris R ButlerNuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, OX1 4BH, UK.
Alexander GerhardDivision of Neuroscience and Experimental Psychology, Wolfson Molecular Imaging Centre, University of Manchester, Manchester, M13 9GB, UK.ORCID https://orcid.org/0000-0002-8071-6062
Simon DucharmeDepartment of Psychiatry, McGill University Health Centre, McGill University, Montreal, H3H 2R9, Québec, Canada.ORCID https://orcid.org/0000-0002-7309-1113
Isabelle Le BerSorbonne Université, Paris Brain Institute-Institut du Cerveau-ICM, Inserm U1127, CNRS UMR 7225, Paris, 75013, France.
Pietro TiraboschiFondazione IRCCS Istituto Neurologico Carlo Besta, Milan, 20133, Italy.
Isabel SantanaNeurology Service, Faculty of Medicine, University Hospital of Coimbra (HUC), University of Coimbra, Coimbra, 3000-214, Portugal.
Florence PasquierUniversity of Lille, Lille, 59000, France.ORCID https://orcid.org/0000-0001-9880-9788
Matthis SynofzikDivision Translational Genomics of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, 72074, Germany.ORCID https://orcid.org/0000-0002-2280-7273
Johannes LevinDepartment of Neurology, Ludwig-Maximilians Universität München, Munich, 80539, Germany.ORCID https://orcid.org/0000-0001-5092-4306
Markus OttoDepartment of Neurology, University of Ulm, Ulm, 89081, Germany.
Sandro SorbiDepartment of Neurofarba, University of Florence, Florence, 50139, Italy.
Jonathan D RohrerDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, WC1N, UK.
Barbara BorroniDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, 25123, Italy.
Coinvestigators GENFI Consortium
Funding
No grant is acknowledged in the PubMed record.
Abstract
The glymphatic system is an emerging target in neurodegenerative disorders. Here, we investigated the activity of the glymphatic system in genetic frontotemporal dementia with a diffusion-based technique called diffusion tensor image analysis along the perivascular space. We investigated 291 subjects with symptomatic or presymptomatic frontotemporal dementia (112 with
Indexed as
DTI-ALPSfrontotemporal dementiafrontotemporal lobar degenerationgeneticglymphatic system
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.