Evidence map›Paper›PMID 39015756›Full record

ArticleFrontiers in nuclear medicine2023

Post-acquisition standardization of positron emission tomography images.

Aliasghar Mortazi, Jayaram K Udupa, Dewey Odhner, Yubing Tong, Drew A Torigian

Abstract read
In one paragraph

Article in Frontiers in nuclear medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Aliasghar MortaziMedical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States.
Jayaram K UdupaMedical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States.
Dewey OdhnerMedical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States.
Yubing TongMedical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States.
Drew A TorigianMedical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States.

Funding

ARRA - ADOPT New Technologies for RDC/CDMSU01CA080098 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI SCHNALL, MITCHELL D. · 1999 to 2011
$182.7M
BIOSTATISTICS DATA MANAGEMENT CENTER FOR ACROINU01CA079778 · NCI · BROWN UNIVERSITY · PI GATSONIS, CONSTANTINE A. · 1999 to 2011
$48.6M
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI A. Clementina Mesaros · 2006 to 2026
$35.3M
Models and methods for automatically measuring disease body-wide and staging disease via FDG-PET/CT in LymphomaR01CA255748 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SCHUSTER, STEPHEN J, TORIGIAN, DREW · 2021 to 2024
$2.3M
Development of a prototype software for automated PET/CT interpretation and reporting in thoracic cancerR41CA236492 · NCI · QUANTITATIVE RADIOLOGY SOLUTIONS, LLC · PI UDUPA, JAYARAM K · 2020 to 2020
$252k
NCI NIH HHS R01 CA255748NCI NIH HHS R41 CA236492NCI NIH HHS U01 CA079778NCI NIH HHS U01 CA080098NIEHS NIH HHS P30 ES013508
6 · The paper itself

Abstract

Purpose: Tissue radiotracer activity measured from positron emission tomography (PET) images is an important biomarker that is clinically utilized for diagnosis, staging, prognostication, and treatment response assessment in patients with cancer and other clinical disorders. Using PET image values to define a normal range of metabolic activity for quantification purposes is challenging due to variations in patient-related factors and technical factors. Although the formulation of standardized uptake value (SUV) has compensated for some of these variabilities, significant non-standardness still persists. We propose an image processing method to substantially mitigate these variabilities. Methods: The standardization method is similar for activity concentration (AC) PET and SUV PET images with some differences and consists of two steps. The Results: Our data set consisted of 84 FDG-PET/CT scans of the body torso including 38 normal subjects and two repeat-scans of 23 patients. We utilized one of two objects-liver and spleen-as a reference object and the other for testing. The proposed standardization method reduced Conclusions: The proposed method is automatic, outperforms current standardization methods, and effectively overcomes the residual variation left over in SUV and inter-scanner variations.

Indexed as

PET standardizationpositron emission tomographystandardized uptake valueSUV variabilitytumor quantification

Identifiers

PMID39015756
PMCPMC11251705

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.