Evidence map›Paper›PMID 39015676›Full record

ArticleMediators of inflammation2024

Dietary Fiber-Derived Microbial Butyrate Suppresses ILC2-Dependent Airway Inflammation in COPD.

Min Jiang, Jing Wang, Zheng Li, Dan Xu, Jing Jing, Fengsen Li, Jianbing Ding, Qifeng Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Min JiangXinjiang Key Laboratory of Respiratory Disease Research Traditional Chinese Medical Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830011, Xinjiang, China.
Jing WangXinjiang Key Laboratory of Respiratory Disease Research Traditional Chinese Medical Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830011, Xinjiang, China.ORCID https://orcid.org/0000-0002-6142-7628
Zheng LiXinjiang Key Laboratory of Respiratory Disease Research Traditional Chinese Medical Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830011, Xinjiang, China.
Dan XuXinjiang Key Laboratory of Respiratory Disease Research Traditional Chinese Medical Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830011, Xinjiang, China.
Jing JingXinjiang Key Laboratory of Respiratory Disease Research Traditional Chinese Medical Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830011, Xinjiang, China.
Fengsen LiXinjiang Key Laboratory of Respiratory Disease Research Traditional Chinese Medical Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830011, Xinjiang, China.ORCID https://orcid.org/0000-0002-8012-3769
Jianbing DingDepartment of Immunology College of Basic Medicine Xinjiang Medical University, Urumqi 830011, Xinjiang, China.ORCID https://orcid.org/0000-0001-5506-7665
Qifeng LiXinjiang Institute of Pediatrics Xinjiang Hospital of Beijing Children's Hospital Children's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830011, Xinjiang, China.ORCID https://orcid.org/0000-0001-9153-2237

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Group 2 innate lymphoid cells (ILC2) strongly modulate COPD pathogenesis. However, the significance of microbiota in ILC2s remains unelucidated. Herein, we investigated the immunomodulatory role of short-chain fatty acids (SCFAs) in regulating ILC2-associated airway inflammation and explores its associated mechanism in COPD. In particular, we assessed the SCFA-mediated regulation of survival, proliferation, and cytokine production in lung sorted ILC2s. To elucidate butyrate action in ILC2-driven inflammatory response in COPD models, we administered butyrate to BALB/c mice via drinking water. We revealed that SCFAs, especially butyrate, derived from dietary fiber fermentation by gut microbiota inhibited pulmonary ILC2 functions and suppressed both IL-13 and IL-5 synthesis by murine ILC2s. Using

Indexed as

ButyratesDietary FiberLymphocytesMice, Inbred BALB CPulmonary Disease, Chronic ObstructiveAnimalsCytokinesFatty Acids, VolatileGastrointestinal MicrobiomeGATA3 Transcription FactorHumansInflammationMaleMiceButyratesCytokinesDietary FiberFatty Acids, VolatileGATA3 Transcription Factor

Identifiers

PMID39015676
PMCPMC11251798

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.