Evidence map›Paper›PMID 39015674›Full record

ArticleStem cells international2024

Safety and Biodistribution of an Autologous Bone Marrow-Derived Mononuclear Cell Infusion into Renal Arteries in Patients with Focal Segmental Glomerulosclerosis: A Phase 1 Study.

Bruno Freire Botelho, André Luis Barreira, Marcio Gomes Filippo, Karina Dutra Asensi, Lanuza A P Faccioli, Anna Beatriz Dos Santos Salgado, Elizabeth Figueiredo de Salles, Carlos Eduardo Cruz Marques, Pedro Leme Silva, Regina Coeli Dos Santos Goldenberg and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Bruno Freire BotelhoDepartment of Nephrology Clementino Fraga Filho University Hospital Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
André Luis BarreiraDepartment of Nephrology Clementino Fraga Filho University Hospital Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Marcio Gomes FilippoDepartment of Vascular Surgery Clementino Fraga Filho University Hospital Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Karina Dutra AsensiCellular and Molecular Cardiology Laboratory Carlos Chagas Filho Biophysics Institute Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Lanuza A P FaccioliCellular and Molecular Cardiology Laboratory Carlos Chagas Filho Biophysics Institute Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Anna Beatriz Dos Santos SalgadoCellular and Molecular Cardiology Laboratory Carlos Chagas Filho Biophysics Institute Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Elizabeth Figueiredo de SallesDepartment of Radiology Clementino Fraga Filho University Hospital Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Carlos Eduardo Cruz MarquesDepartment of Radiology Clementino Fraga Filho University Hospital Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Pedro Leme SilvaLaboratory of Pulmonary Investigation Carlos Chagas Filho Biophysics Institute Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Regina Coeli Dos Santos GoldenbergPrecision Medicine Research Center Carlos Chagas Filho Institute of Biophysics e Brazilian Institute of Science and Technology-INCT REGENERA, Rio de Janeiro, Brazil.
Angelo MaiolinoDepartment of Hematology Clementino Fraga Filho University Hospital Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Bianca GutfilenDepartment of Radiology Clementino Fraga Filho University Hospital Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Sergio Augusto Lopes de SouzaDepartment of Radiology Clementino Fraga Filho University Hospital Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Maurilo Leite JuniorDepartment of Nephrology Clementino Fraga Filho University Hospital Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Marcelo Marcos MoralesLaboratory of Cellular and Molecular Physiology Carlos Chagas Filho Biophysics Institute Health Sciences Center Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-3742-2050

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with focal segmental glomerulosclerosis (FSGS) who are refractory to drug treatment may present progressive loss of kidney function, leading to chronic kidney disease stage 5 under dialysis treatment. The safety of systemic administration of bone marrow-derived mononuclear cells (BMDMCs) has been shown in different preclinical models of kidney diseases. However, to date, no study has evaluated the safety and biodistribution of BMDMCs after infusion in renal arteries in patients with FSGS. We used a prospective, non-randomized, single-center longitudinal design to investigate this approach. Five patients with refractory FSGS and an estimated glomerular filtration rate (eGFR) between 20 and 40 ml/min/1.73 m

Identifiers

PMID39015674
PMCPMC11251782

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.