Evidence map›Paper›PMID 39015662›Full record

ArticleJHLT open2024

Mechanical Circulatory Support in Pediatric Myocarditis: Support Strategies and Outcomes in a Nationally Representative Cohort.

Alicia M Kamsheh, Jonathan B Edelson, Jennifer Faerber, Antara Mondal, William Quarshie, Jonathan J Edwards, Kimberly Y Lin, Matthew J O'Connor, Carol Wittlieb-Weber, Katsuhide Maeda and 2 more

Abstract read
In one paragraph

Article in JHLT open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Acute and Chronic Myocarditis in Men and Women.Current heart failure reports · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alicia M KamshehDivision of Pediatric Cardiology, Washington University School of Medicine, St. Louis, MO.
Jonathan B EdelsonDivision of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA.
Jennifer FaerberData Science and Biostatistics Unit, Children's Hospital of Philadelphia, Philadelphia, PA.
Antara MondalData Science and Biostatistics Unit, Children's Hospital of Philadelphia, Philadelphia, PA.
William QuarshieData Science and Biostatistics Unit, Children's Hospital of Philadelphia, Philadelphia, PA.
Jonathan J EdwardsDivision of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA.
Kimberly Y LinDivision of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA.
Matthew J O'ConnorDivision of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA.
Carol Wittlieb-WeberDivision of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA.
Katsuhide MaedaDivision of Cardiothoracic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA.
Michael P GoldsmithDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.
Joseph W RossanoDivision of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA.

Funding

Training in Molecular Therapeutics for Pediatric CardiologyT32HL007915 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Robert J Levy, JOSEPH W ROSSANO · 1999 to 2026
$13.4M
Defining the Role of ROR2 in Right Ventricular Failure PathogenesisK08HL159311 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI EDWARDS, JONATHAN JOSEPH · 2021 to 2025
$657k
NHLBI NIH HHS K08 HL159311NHLBI NIH HHS T32 HL007915
6 · The paper itself

Abstract

Background: Myocarditis is a common cause of pediatric heart failure which may require mechanical circulatory support (MCS). The purpose of this study is to describe MCS strategies used in a nationwide cohort of pediatric patients with myocarditis, identify trends over time, and compare outcomes between MCS strategies. Methods: This study utilized the Kids' Inpatient Database (KID), a national sample of administrative discharge data. KID admissions from 2003-2016 were queried using ICD-9/10 codes to identify those with a diagnosis of myocarditis. MCS outcomes were compared using logistic regression. Results: Of 5,661 admissions for myocarditis, MCS was used in 424 (7.5%), comprised of extracorporeal membrane oxygenation (ECMO) in 312 (73.6%), including 32 (10.2%) instances of extracorporeal cardiopulmonary resuscitation (ECPR), temporary ventricular assist devices (tVAD) in 28 (6.6%), durable VAD (dVAD) in 42 (9.9%) and combination MCS in 42 (9.9%). MCS use increased over time (p=0.031), but MCS strategies did not significantly change. Mortality was high in the MCS group (28.3%). There was no difference in odds of death in the VAD only or combination MCS group compared to the non-ECPR ECMO group (p=0.07 and p=0.65, respectively). Conclusion: MCS is used in 1 in 13 pediatric myocarditis cases, and MCS use is increasing over time with ECMO remaining the most frequently used modality. Mortality remains high in patients that receive MCS but does not differ between those receiving VAD or combination MCS as compared to non-ECPR ECMO on unadjusted analysis. Further prospective analysis is required to evaluate the relative effectiveness of MCS modalities in this disease.

Identifiers

PMID39015662
PMCPMC11251716

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.