Evidence map›Paper›PMID 39015283›Full record

ArticleACS medicinal chemistry letters2024

Evaluation of Antibacterial Functionalized Dihydropyrimidine Photoaffinity Probes Toward Mechanism of Action Studies.

Christopher M Russo, Zachary W Boyer, Kaitlyn Scheunemann, Jonathan Farren, Alexandra Minich, Cody J Wenthur, Matthew C O'Reilly

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christopher M RussoDepartment of Chemistry, Villanova University, Villanova, Pennsylvania 19085, United States.
Zachary W BoyerDepartment of Chemistry, Villanova University, Villanova, Pennsylvania 19085, United States.
Kaitlyn ScheunemannDepartment of Chemistry and Biotechnology, University of Wisconsin-River Falls, River Falls, Wisconsin 54022, United States.
Jonathan FarrenDepartment of Chemistry and Biotechnology, University of Wisconsin-River Falls, River Falls, Wisconsin 54022, United States.
Alexandra MinichSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Cody J WenthurSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.ORCID https://orcid.org/0000-0001-6043-3842
Matthew C O'ReillyDepartment of Chemistry, Villanova University, Villanova, Pennsylvania 19085, United States.ORCID https://orcid.org/0000-0002-9175-4179

Funding

Development of Allosteric Dihydrofolate Reductase Inhibitors: Exploration of a Novel Inhibitory Mechanism for a Validated Antibiotic TargetR15GM140412 · NIGMS · VILLANOVA UNIVERSITY · PI O'REILLY, MATTHEW C · 2021 to 2021
$341k
NIGMS NIH HHS R15 GM140412
6 · The paper itself

Abstract

Antibiotic-resistant bacteria are a global health concern, necessitating the development of antibiotics working through new or underutilized mechanisms. Functionalized amino dihydropyrimidines have previously demonstrated potential as antibacterial agents, but they had limited potency, and their biological mechanism was not understood. To further evaluate their potential, focused libraries were prepared and screened for bacterial growth inhibition, and these compounds provided additional insights into the structure-activity relationships, allowing for the preparation of compounds that inhibited all strains of

Identifiers

PMID39015283
PMCPMC11247627

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.