Evidence map›Paper›PMID 39015238›Full record

ArticleCase reports in ophthalmology

A Case of Inflammatory Juvenile Conjunctival Nevus with a Rare Histopathological Type.

Chihiro Iwata, Yuichi Asahina, Takashi Ono, Yukako Taketani, Mikiko Kimakura, Tetsuya Toyono, Mariko Tanaka, Makoto Aihara, Takashi Miyai

Abstract readCase Reports
In one paragraph

Article in Case reports in ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Chihiro IwataDepartment of Ophthalmology, University of Tokyo Hospital, Tokyo, Japan.
Yuichi AsahinaDepartment of Ophthalmology, University of Tokyo Hospital, Tokyo, Japan.
Takashi OnoDepartment of Ophthalmology, University of Tokyo Hospital, Tokyo, Japan.
Yukako TaketaniDepartment of Ophthalmology, University of Tokyo Hospital, Tokyo, Japan.
Mikiko KimakuraDepartment of Ophthalmology, University of Tokyo Hospital, Tokyo, Japan.
Tetsuya ToyonoDepartment of Ophthalmology, University of Tokyo Hospital, Tokyo, Japan.
Mariko TanakaDepartment of Pathology, University of Tokyo Hospital, Tokyo, Japan.
Makoto AiharaDepartment of Ophthalmology, University of Tokyo Hospital, Tokyo, Japan.
Takashi MiyaiDepartment of Ophthalmology, University of Tokyo Hospital, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Inflammatory juvenile conjunctival nevus (IJCN) is a rare condition affecting both children and adolescents. It has misleading clinical and histopathological features; therefore, careful assessment is necessary. We present a case of IJCN with a rare pathological type and misleading histopathological features. Case Presentation: A 13-year-old girl with IJCN in the right eye was treated with antiallergic and steroid eye drops but showed no response and was referred to our hospital for excisional biopsy. Slit-lamp examination revealed a nonpigmented juxtalimbal tumor in the right eye. Histopathologically, nevus cells with mild nuclear atypia proliferated within the conjunctival epithelium. Confluent growth of junctional nests, conjunctival cysts, and prominent inflammatory infiltration were also observed. Considering the young age of the patient and immunohistochemical characteristics (HMB-45, SOX10, p16 and Ki-67), the patient was finally diagnosed with IJCN. IJCN has three pathological subtypes - compound, subepithelial, and junctional - depending on the location of the nevus cells. This case was diagnosed as a rare junctional type, as most of the examined sections only showed lesions within the epithelium; no lesions were clearly identified extending beneath the epithelium. Conclusion: The pathological diagnosis of IJCN is difficult because some features of IJCN suggest malignancy. Detailed microscopic examination, immunohistochemical staining, and the patient's young age helped render a final diagnosis.

Indexed as

Case reportHistopathologyInflammatory juvenile conjunctival nevus

Identifiers

PMID39015238
PMCPMC11250155

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