Evidence map›Paper›PMID 39015150›Full record

ArticleiScience2024

Supernumerary proteins of the human mitochondrial ribosomal small subunit are integral for assembly and translation.

Taru Hilander, Ryan Awadhpersad, Geoffray Monteuuis, Krystyna L Broda, Max Pohjanpelto, Elizabeth Pyman, Sachin Kumar Singh, Tuula A Nyman, Isabelle Crevel, Robert W Taylor and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Vacuolar-type HNature communications · 2025
    Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Taru HilanderGenetics Section, Cardiovascular and Genomics Research Institute, St George's, University of London, London, UK.
Ryan AwadhpersadDepartment of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Geoffray MonteuuisDepartment of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Krystyna L BrodaGenetics Section, Cardiovascular and Genomics Research Institute, St George's, University of London, London, UK.
Max PohjanpeltoGenetics Section, Cardiovascular and Genomics Research Institute, St George's, University of London, London, UK.
Elizabeth PymanGenetics Section, Cardiovascular and Genomics Research Institute, St George's, University of London, London, UK.
Sachin Kumar SinghDepartment of Immunology, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway.
Tuula A NymanDepartment of Immunology, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway.
Isabelle CrevelCore Facilities, St George's, University of London, London, UK.
Robert W TaylorMitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Ann SaadaDepartment of Genetics, Hadassah Medical Center & Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112001 Israel.
Diego BalboaStem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland.
Brendan J BattersbyInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Christopher B JacksonDepartment of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Christopher J CarrollGenetics Section, Cardiovascular and Genomics Research Institute, St George's, University of London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial ribosomes (mitoribosomes) have undergone substantial evolutionary structural remodeling accompanied by loss of ribosomal RNA, while acquiring unique protein subunits located on the periphery. We generated CRISPR-mediated knockouts of all 14 unique (mitochondria-specific/supernumerary) human mitoribosomal proteins (snMRPs) in the small subunit to study the effect on mitoribosome assembly and protein synthesis, each leading to a unique mitoribosome assembly defect with variable impact on mitochondrial protein synthesis. Surprisingly, the stability of mS37 was reduced in all our snMRP knockouts of the small and large ribosomal subunits and patient-derived lines with mitoribosome assembly defects. A redox-regulated CX

Indexed as

biochemistrybiological sciencescell biologymolecular biology

Identifiers

PMID39015150
PMCPMC11251090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.