Evidence map›Paper›PMID 39015146›Full record

ArticleiScience2024

The E3 ubiquitin ligase Nedd4L preserves skeletal muscle stem cell quiescence by inhibiting their activation.

Darren M Blackburn, Korin Sahinyan, Aldo Hernández-Corchado, Felicia Lazure, Vincent Richard, Laura Raco, Gabrielle Perron, René P Zahedi, Christoph H Borchers, Christoph Lepper and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Darren M BlackburnDepartment of Human Genetics, McGill University, 3640 rue University, Montréal, QC H3A 0C7, Canada.
Korin SahinyanDepartment of Human Genetics, McGill University, 3640 rue University, Montréal, QC H3A 0C7, Canada.
Aldo Hernández-CorchadoDepartment of Human Genetics, McGill University, 3640 rue University, Montréal, QC H3A 0C7, Canada.
Felicia LazureDepartment of Human Genetics, McGill University, 3640 rue University, Montréal, QC H3A 0C7, Canada.
Vincent RichardSegal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, QC H3T 1E2, Canada.
Laura RacoLady Davis Institute for Medical Research, Jewish General Hospital, 3755 Chemin de la Côte- Sainte-Catherine, Montréal, QC H3T 1E2, Canada.
Gabrielle PerronDepartment of Human Genetics, McGill University, 3640 rue University, Montréal, QC H3A 0C7, Canada.
René P ZahediSegal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, QC H3T 1E2, Canada.
Christoph H BorchersSegal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, QC H3T 1E2, Canada.
Christoph LepperDepartment of Physiology & Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, USA.
Hiroshi KawabeDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine 37075 Göttingen, Germany.
Arezu Jahani-AslDepartment of Cellular and Molecular Medicine and University of Ottawa Brain and Mind Research Institute, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.
Hamed S NajafabadiDepartment of Human Genetics, McGill University, 3640 rue University, Montréal, QC H3A 0C7, Canada.
Vahab D SoleimaniDepartment of Human Genetics, McGill University, 3640 rue University, Montréal, QC H3A 0C7, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult stem cells play a critical role in tissue repair and maintenance. In tissues with slow turnover, including skeletal muscle, these cells are maintained in a mitotically quiescent state yet remain poised to re-enter the cell cycle to replenish themselves and regenerate the tissue. Using a panomics approach we show that the PAX7/NEDD4L axis acts against muscle stem cell activation in homeostatic skeletal muscle. Our findings suggest that PAX7 transcriptionally activates the E3 ubiquitin ligase Nedd4L and that the conditional genetic deletion of Nedd4L impairs muscle stem cell quiescence, with an upregulation of cell cycle and myogenic differentiation genes. Loss of Nedd4L in muscle stem cells results in the expression of doublecortin (DCX), which is exclusively expressed during their

Indexed as

biochemistrybiological sciencescell biologynatural sciencesstem cells research

Identifiers

PMID39015146
PMCPMC11250905

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.