Evidence map›Paper›PMID 39015094›Full record

ArticleChemMedChem2024

Exploring Novel Coumarin-Tethered Bis-Triazoles: Apoptosis Induction in Human Pancreatic Cancer Cells, Antimicrobial Effects, and Molecular Modelling Investigations.

Sanjeev Dhawan, Ashona Singh, Neha Manhas, Pule Seboletswe, Lungisani Khubone, Gobind Kumar, Sreekantha B Jonnalagadda, Asif Raza, Arun K Sharma, Parvesh Singh

Abstract read
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In one paragraph

Article in ChemMedChem, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sanjeev DhawanSchool of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, 4000, South Africa.
Ashona SinghSchool of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, 4000, South Africa.
Neha ManhasSchool of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, 4000, South Africa.
Pule SeboletsweSchool of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, 4000, South Africa.
Lungisani KhuboneSchool of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, 4000, South Africa.
Gobind KumarSchool of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, 4000, South Africa.
Sreekantha B JonnalagaddaSchool of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, 4000, South Africa.
Asif RazaDepartment of Pharmacology, Penn State College of Medicine, Penn State Cancer Institute, CH72, 500 University Drive, Hershey, PA 17033, USA.
Arun K SharmaDepartment of Pharmacology, Penn State College of Medicine, Penn State Cancer Institute, CH72, 500 University Drive, Hershey, PA 17033, USA.
Parvesh SinghSchool of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, 4000, South Africa.ORCID 0000-0001-6742-6389

Funding

Wellcome Trust
6 · The paper itself

Abstract

In the present study, we identified that two representative compounds (7 c and 9 f) of our newly synthesized coumarin-tagged bis-triazoles induced apoptosis in human pancreatic cells (PANC-1) by caspase 3/7mediated pathway. Both 7 c and 9 f (IC

Indexed as

Antineoplastic AgentsApoptosisCoumarinsPancreatic NeoplasmsTriazolesAnti-Bacterial AgentsCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorErbB ReceptorsHumansMicrobial Sensitivity TestsModels, MolecularMolecular Docking SimulationMolecular StructureAnti-Bacterial AgentsAntineoplastic AgentscoumarinCoumarinsErbB ReceptorsTriazoles1,2,3-triazoleAntimicrobialAnti-pancreatic cancerApoptosiscLogPCoumarinPANC-1TPSA

Identifiers

PMID39015094
PMCPMC11581422

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.