Evidence map›Paper›PMID 39014963›Full record

Trial reportJournal of the International Society of Sports Nutrition2024

Acute, dose-response effects of guayusa leaf extract on mood, cognitive and motor-cognitive performance, and blood pressure, heart rate, and ventricular repolarization.

Nathaniel J Helwig, Laura E Schwager, Alexander C Berry, Anna C Zucker, Jacob S Venenga, Samantha C Sterbenz, Nathaniel D M Jenkins

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nathaniel J HelwigUniversity of Iowa, Department of Health and Human Physiology, Iowa City, IA, USA.
Laura E SchwagerUniversity of Iowa, Department of Health and Human Physiology, Iowa City, IA, USA.
Alexander C BerryUniversity of Iowa, Department of Health and Human Physiology, Iowa City, IA, USA.
Anna C ZuckerUniversity of Iowa, Department of Health and Human Physiology, Iowa City, IA, USA.
Jacob S VenengaUniversity of Iowa, Department of Health and Human Physiology, Iowa City, IA, USA.
Samantha C SterbenzUniversity of Iowa, Department of Health and Human Physiology, Iowa City, IA, USA.
Nathaniel D M JenkinsUniversity of Iowa, Department of Health and Human Physiology, Iowa City, IA, USA.ORCID 0000-0003-1781-3414

Funding

The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
NCATS NIH HHS UL1 TR002537
6 · The paper itself

Abstract

purposeWe conducted a randomized, double-blind, placebo-controlled crossover trial in young adults to examine the dose-dependent (600 mg versus 1200 mg), acute effects of consumption of an

methodsTwenty-five adults (mean ± SD, age = 28 ± 7 y; 9 M/16 F) completed familiarization and then three randomly ordered experimental visits where they consumed either 600 mg (GLE

resultsGLE

conclusionsThe goal of GLE supplementation should be considered when selecting a dosing strategy. Lower dosages of GLE (e.g. 600 mg) appear to optimize cognitive and mood-related outcomes while limiting side-effects such as jitteriness in women, and higher dosages may be necessary (e.g. 1200 mg) to promote improvements in motor-cognitive performance.

Indexed as

AffectBlood PressureCognitionCross-Over StudiesDose-Response Relationship, DrugHeart RatePlant ExtractsAdultDietary SupplementsDouble-Blind MethodFemaleHumansMalePlant LeavesYoung AdultPlant ExtractsCaffeinecardiovascularcognitiondietary supplementationtea extract

Identifiers

PMID39014963
PMCPMC11257001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.