Evidence map›Paper›PMID 39014393›Full record

ArticleActa neuropathologica communications2024

Papillary tumor of the pineal region: analysis of DNA methylation profiles and clinical outcomes in 76 cases.

Zhichao Wu, Karen Dazelle, Zied Abdullaev, Hye-Jung Chung, Sonika Dahiya, Matthew Wood, Han Lee, Calixto-Hope G Lucas, Qinwen Mao, Lorraina Robinson and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Histopathology and Molecular Pathology of Pineal Region Tumors.Advances and technical standards in neurosurgery · 2026
    Review
  5. Pineal Gland Parenchyma Tumors.Advances and technical standards in neurosurgery · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Zhichao WuLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr., Room 2S235, Bethesda, MD, 20892, USA.
Karen DazelleLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr., Room 2S235, Bethesda, MD, 20892, USA.
Zied AbdullaevLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr., Room 2S235, Bethesda, MD, 20892, USA.
Hye-Jung ChungLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr., Room 2S235, Bethesda, MD, 20892, USA.
Sonika DahiyaDivision of Neuropathology, Washington University, St. Louis, MO, USA.
Matthew WoodDepartment of Pathology and Laboratory Medicine, Oregon Health & Science University, Portland, OR, USA.
Han LeeNeuropathology Division, Department of Pathology, University of California Davis, Sacramento, CA, USA.
Calixto-Hope G LucasDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Qinwen MaoDepartment of Pathology, Primary Children's Hospital, Salt Lake City, UT, USA.
Lorraina RobinsonDepartment of Pathology, Primary Children's Hospital, Salt Lake City, UT, USA.
Igor FernandesLaboratorio Bacchi, São Paulo, Brazil.
Matthew McCordDepartment of Pathology, Northwestern Memorial Hospital, Chicago, IL, USA.
Peter PytelDepartment of Pathology, University of Chicago, Chicago, IL, USA.
Kyle S ConwayDepartment of Pathology, University of Michigan Medical Center, Ann Arbor, MI, USA.
Rebecca YodaDepartment of Pathology, University of Washington, Seattle, WA, USA.
Jennifer M EschbacherDepartment of Neuropathology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
Ossama M MaherDivision of Pediatric Neuro -Oncology, Pediatric Hematology and Oncology, Kidz Medical Services, Nicklaus Children's Hospital, Miami, FL, USA.
Martin HasselblattInstitute of Neuropathology, University Hospital Münster, Münster, Germany.
Bret C MobleyDepartment of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN, USA.
Jack M RaisanenDivision of Neuropathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kimmo J HatanpaaDivision of Neuropathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Joshua ByersDepartment of Laboratory Medicine, University of California-San Francisco, San Francisco, CA, USA.
Norman L LehmanDepartment of Pathology, Baylor College of Medicine, Baylor Scott & White Medical Center, Temple, TX, USA.
Patrick J CiminoSurgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Drew PrattLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr., Room 2S235, Bethesda, MD, 20892, USA.
Martha QuezadoLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr., Room 2S235, Bethesda, MD, 20892, USA.
Kenneth AldapeLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr., Room 2S235, Bethesda, MD, 20892, USA. kenneth.aldape@nih.gov.ORCID 0000-0001-5119-7550

Funding

Single-cell DNA methylation analysis of human cancerZIABC011846 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ALDAPE, KENNETH · 2018 to 2025
$8.4M
Genomic Biomarkers of CancerZIABC011850 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ALDAPE, KENNETH · 2019 to 2025
$5.1M
6 · The paper itself

Abstract

Papillary tumor of the pineal region (PTPR) is an uncommon tumor of the pineal region with distinctive histopathologic and molecular characteristics. Experience is limited with respect to its molecular heterogeneity and clinical characteristics. Here, we describe 39 new cases and combine these with 37 previously published cases for a cohort of 76 PTPR's, all confirmed by methylation profiling. As previously reported, two main methylation groups were identified (PTPR-A and PTPR-B). In our analysis we extended the subtyping into three subtypes: PTPR-A, PTPR-B1 and PTPR-B2 supported by DNA methylation profile and genomic copy number variations. Frequent loss of chromosome 3 or 14 was found in PTPR-B1 tumors but not in PTPR-B2. Examination of clinical outcome showed that nearly half (14/30, 47%) of examined patients experienced tumor progression with significant difference among the subtypes (p value = 0.046). Our analysis extends the understanding of this uncommon but distinct neuroepithelial tumor by describing its molecular heterogeneity and clinical outcomes, including its tendency towards tumor recurrence.

Indexed as

DNA MethylationPineal GlandPinealomaAdolescentAdultAgedBrain NeoplasmsChildChild, PreschoolDNA Copy Number VariationsFemaleHumansMaleMiddle AgedYoung Adult

Identifiers

PMID39014393
PMCPMC11251120

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.