Evidence map›Paper›PMID 39014373›Full record

ArticleMicrobial cell factories2024

Metabolic engineering of Komagataella phaffii for the efficient utilization of methanol.

Yuanyuan Wang, Ruisi Li, Fengguang Zhao, Shuai Wang, Yaping Zhang, Dexun Fan, Shuangyan Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial cell factories, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Synthetic and systems biotechnology · 2025
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuanyuan Wang *Guangdong Key Laboratory of Fermentation and Enzyme Engineering, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China.
Ruisi Li *Guangdong Key Laboratory of Fermentation and Enzyme Engineering, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China.
Fengguang ZhaoSchool of Light Industry and Engineering, South China University of Technology, Guangzhou, China.
Shuai WangGuangdong Key Laboratory of Fermentation and Enzyme Engineering, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China.
Yaping ZhangGuangdong Key Laboratory of Fermentation and Enzyme Engineering, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China.
Dexun FanGuangdong Key Laboratory of Fermentation and Enzyme Engineering, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China.
Shuangyan HanGuangdong Key Laboratory of Fermentation and Enzyme Engineering, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China. syhan@scut.edu.cn.

Funding

National Key Research and Development Program of China 2022YFC2105501
6 · The paper itself

Abstract

backgroundKomagataella phaffii, a type of methanotrophic yeast, can use methanol, a favorable non-sugar substrate in eco-friendly bio-manufacturing. The dissimilation pathway in K. phaffii leads to the loss of carbon atoms in the form of CO

resultsInhibiting the dissimilation pathway triggers an excessive accumulation of formaldehyde and a decline in the intracellular NAD

conclusionsThe reduction of formaldehyde accumulation, the increase of NAD

Indexed as

Metabolic EngineeringMethanolSaccharomycetalesAlcohol OxidoreductasesAldehyde OxidoreductasesFormaldehydeNADalcohol oxidaseAlcohol OxidoreductasesAldehyde OxidoreductasesFormaldehydeformaldehyde dehydrogenase, glutathione-independentMethanolNADFormaldehydeKomagataella PhaffiiMethanolNAD+/NADHXu5P

Identifiers

PMID39014373
PMCPMC11253385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.