Evidence map›Paper›PMID 39014359›Full record

ArticleBMC cardiovascular disorders2024

Comparison of warfarin, rivaroxaban, and dabigatran for effectiveness and safety in atrial fibrillation patients with different CHA2DS2-VASc scores: a retrospective cohort study.

Yue Zhao, Hong Ren, Shiwei Xu

Abstract readComparative Study
In one paragraph

Article in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Frontiers in cardiovascular medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yue ZhaoDepartment of Pharmacy, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, P.R. China.
Hong RenDepartment of Pharmacy Intravenous Admixture Service, the First Affiliated Hospital of Harbin Medical University, Harbin, 150001, P.R. China.
Shiwei XuDepartment of Pharmacy, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, P.R. China. Xushiwei@hrbmu.edu.cn.

Funding

Key Project of Science Popularization Research on the National Medical Information Network of the Chinese Pharmaceutical Association CMEI2022KPYJ00563Postdoctoral Scientific Research Development Fund of Heilongjiang Province LBH-Z 20167
6 · The paper itself

Abstract

backgroundThis retrospective cohort study aims to compare the effectiveness and safety of warfarin, rivaroxaban, and dabigatran in atrial fibrillation (AF) patients with different CHA2DS2-VASc scores in northern China.

methodsA retrospective cohort study was performed to evaluate anticoagulation in AF patients at the second affiliated hospital of Harbin Medical University from September 2018 to August 2019. Patients included in this study (n = 806) received warfarin (n = 300), or rivaroxaban (n = 203), or dabigatran (n = 303). Baseline characteristics and follow-up data including adherence, bleeding events and ischemic stroke (IS) events were collected.

resultsPatients receiving rivaroxaban (73.9%) or dabigatran (73.6%) showed better adherence than those receiving warfarin (56.7%). Compared with warfarin-treated patients, dabigatran-treated patients had lower incidence of bleeding events (10.9% vs 19.3%, χ

conclusionCompared with warfarin therapy, patients with different CHA2DS2-VASc scores receiving either rivaroxaban or dabigatran were associated with higher persistence. AF patients with score ≥ 4 were more likely to experience IS events while hemorrhagic tendency preferred patients with low score 0-1.

Indexed as

AnticoagulantsAtrial FibrillationDabigatranHemorrhageRivaroxabanWarfarinAgedAged, 80 and overAntithrombinsBlood CoagulationChinaDecision Support TechniquesFactor Xa InhibitorsFemaleHumansMaleAnticoagulantsAntithrombinsDabigatranFactor Xa InhibitorsRivaroxabanWarfarinAtrial fibrillationCHA2DS2-VASc scoreDabigatranRivaroxabanWarfarin

Identifiers

PMID39014359
PMCPMC11251110

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.