Evidence map›Paper›PMID 39014305›Full record

ArticleBMC neurology2024

Diffusion spectrum imaging in patients with idiopathic normal pressure hydrocephalus: correlation with ventricular enlargement.

Qian Wu, Wenjie He, Chenyuan Liu, Xiaolin Yang, Jiakuan Chen, Boyan Xu, Xi Zhou, Guodong Huang, Jun Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qian Wu *Department of Radiology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen University, 3002 SunGang Road West, Shenzhen, Guangdong Province, 518035, China.
Wenjie He *Department of Radiology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen University, 3002 SunGang Road West, Shenzhen, Guangdong Province, 518035, China.
Chenyuan LiuFive-year Clinical Medicine, Xiangya School of Medicine, Central South University, Changsha, Hunan Province, 410083, China.
Xiaolin YangLonggang Central Hospital of Shenzhen, Shenzhen, China.
Jiakuan ChenDepartment of Radiology, South China Hospital, Medical School, Shenzhen University, Shenzhen, 518116, China.
Boyan XuMR Research, GE Healthcare, Beijing, 100076, China.
Xi ZhouDepartment of Radiology, South China Hospital, Medical School, Shenzhen University, Shenzhen, 518116, China.
Guodong Huang *Department of Neurosurgery, Shenzhen Second people's hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen University, 3002 SunGang Road West, Shenzhen, Guangdong Province, 518035, China. huangguodong@email.szu.edu.cn.
Jun Xia *Department of Radiology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen University, 3002 SunGang Road West, Shenzhen, Guangdong Province, 518035, China. xiajun@email.szu.edu.cn.

Funding

National Natural Science Foundation of China 82171913Shenzhen Research and Development Program JCYJ20220818101816036
6 · The paper itself

Abstract

backgroundTo investigate the association between white matter changes and ventricular expansion in idiopathic normal pressure hydrocephalus (iNPH) based on diffusion spectrum imaging (DSI).

methodsWe included 32 patients with iNPH who underwent DSI using a 3T MRI scanner. The lateral ventricles were manually segmented, and ventricular volumes were measured. Two methods were utilised in the study: manual region-of-interest (ROI) delineation and tract diffusion profile analysis. General fractional anisotropy (GFA) and fractional anisotropy (FA) were extracted in different white matter regions, including the bilateral internal capsule (anterior and posterior limbs) and corpus callosum (body, genu, and splenium) with manual ROI delineation. The 18 main tracts in the brain of each patient were extracted; the diffusion metrics of 100 equidistant nodes on each fibre were calculated, and Spearman's correlation coefficient was used to determine the correlation between diffusion measures and ventricular volume of iNPH patients.

resultsThe GFA and FA of all ROI showed no significant correlation with lateral ventricular volume. However, in the tract diffusion profile analysis, lateral ventricular volume was positively correlated with part of the cingulum bundle, left corticospinal tract, and bilateral thalamic radiation posterior, whereas it was negatively correlated with the bilateral cingulum parahippocampal (all p < 0.05).

conclusionsThe effect of ventricular enlargement in iNPH on some white matter fibre tracts around the ventricles was limited and polarizing, and most white matter fibre tract integrity changes were not associated with ventricular enlargement; this reflects that multiple pathological mechanisms may have been combined to cause white matter alterations in iNPH.

Indexed as

Hydrocephalus, Normal PressureWhite MatterAgedAged, 80 and overAnisotropyCerebral VentriclesDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingFemaleHumansMaleMiddle AgedDiffusion spectrum imagingIdiopathic normal pressure hydrocephalusWhite matter

Identifiers

PMID39014305
PMCPMC11251323

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