Evidence map›Paper›PMID 39014197›Full record

ArticleLeukemia2024

FBXL6 is a vulnerability in AML and unmasks proteolytic cleavage as a major experimental pitfall in myeloid cells.

Anna Sperk, Antje Gabriel, Daniela Koch, Abirami Augsburger, Victoria Sanchez, David Brockelt, Rupert Öllinger, Thomas Engleitner, Piero Giansanti, Romina Ludwig and 9 more

Abstract readLetter
In one paragraph

Article in Leukemia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Anna SperkDepartment of Medicine III, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Antje GabrielDepartment of Medicine III, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID 0009-0009-8197-7369
Daniela KochDepartment of Medicine III, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Abirami AugsburgerDepartment of Medicine III, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Victoria SanchezMass Spectrometry Core Facility, Max Planck Institute of Biochemistry, Martinsried, Germany.
David BrockeltDepartment of Medicine III, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Rupert ÖllingerTranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.
Thomas EngleitnerTranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.
Piero GiansantiTranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.ORCID 0000-0003-2857-0841
Romina LudwigResearch Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Munich, Germany.
Priska Auf der MaurDepartment of Medicine III, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID 0000-0002-9059-8979
Wencke WalterMLL Munich Leukemia Laboratory, Munich, Germany.ORCID 0000-0002-5083-9838
Torsten HaferlachMLL Munich Leukemia Laboratory, Munich, Germany.ORCID 0000-0003-0196-2837
Irmela JeremiasResearch Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Munich, Germany.ORCID 0000-0003-1773-7677
Roland RadTranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.
Barbara SteigenbergerMass Spectrometry Core Facility, Max Planck Institute of Biochemistry, Martinsried, Germany.
Bernhard KusterProteomics and Bioanalytics, School of Life Sciences, Technical University of Munich, Freising, Germany.
Ruth Eichner *Department of Medicine III, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. ruth.eichner@tum.de.ORCID 0000-0002-8433-9452
Florian Bassermann *Department of Medicine III, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. florian.bassermann@tum.de.ORCID 0000-0003-4435-2609

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) BA 2851/6-1Deutsche Forschungsgemeinschaft (German Research Foundation) BA 2851/7-1Deutsche Forschungsgemeinschaft (German Research Foundation) EI1131/1-1 FOR 5560EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 682473Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) P500PB_222048
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

F-Box ProteinsLeukemia, Myeloid, AcuteMyeloid CellsProteolysisHumansF-Box Proteins

Identifiers

PMID39014197
PMCPMC11347359

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.