SynthesisSpinal cord2024
Bowel burdens: a systematic review and meta-analysis examining the relationships between bowel dysfunction and quality of life after spinal cord injury.
Synthesis in Spinal cord, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Spinal cord stimulation to manage autonomic dysfunction after spinal cord injury: a systematic review.Frontiers in human neuroscience · 2026Pooled it
- Spinal Cord Ischemia After Thoracoabdominal Aortic Aneurysm Repair: Pathophysiology, Detection, and Management.Neurology international · 2026Review
- Neurogenic Pelvic Floor Dysfunctions Across Neurological Disorders: Mechanisms, Phenotypes, and Precision Rehabilitation Pathways-A Narrative Review.Journal of clinical medicine · 2026Review
- Unveiling the Clinical Impact of Lower Limb Robotic Devices in Neurorehabilitation: An Umbrella Review.Annals of biomedical engineering · 2026Review
- Perceived burdensomeness and thwarted belongingness in persons living with spinal cord injuries and disorders.Spinal cord · 2026Article
- Probiotic and Prebiotic Supplementation for Gastrointestinal Discomfort in Chronic Spinal Cord Injury (PRO-GIDSCI): A Randomized Controlled Crossover Trial Protocol.Methods and protocols · 2026Article
- Gastrointestinal Diagnostic Coding After Spinal Cord Injury: Health Behavior Correlates and Implications for Neurogenic Bowel Management in a Nationwide Claim-Based Cohort.Journal of clinical medicine · 2026Article
- Evolution of bowel function and quality of life after spinal cord injury: a longitudinal registry and survey study.Journal of rehabilitation medicine · 2026Article
- At-home feasibility trial of genital nerve stimulation to modulate neurogenic bowel dysfunction in individuals living with spinal cord injury: a protocol.Frontiers in neurology · 2026Article
- Gaps in recovery priorities between individuals with spinal cord injury and healthcare professionals.npj health systems · 2026Article
- Functional improvements correlate with enhanced quality of life following mesenchymal stromal cell therapy in chronic spinal cord injury.Scientific reports · 2025Article
- Article
- Bowel Dysfunctions in Young Adults with Multiple Sclerosis: A Retrospective Study.Medical sciences (Basel, Switzerland) · 2025Article
- On-Line Survey About Autonomic Dysreflexia in Individuals with Spinal Cord Injury in Croatia.Journal of clinical medicine · 2025Article
- Constructing and applying a tiered family engagement strategy for managing neurogenic bowel dysfunction in TSCI patients.Frontiers in neurology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designSystematic review and meta-analysis.
objectivesMany individuals with spinal cord injury (SCI) experience autonomic dysfunction, including profound impairments to bowel and cardiovascular function. Neurogenic bowel dysfunction (NBD) is emerging as a potential determinant of quality of life (QoL) after SCI. For individuals with high-level lesions ( > T6), bowel care-related autonomic dysreflexia (B-AD; profound episodic hypertension) further complicates bowel care. We aimed to evaluate the extent of bowel dysfunction after SCI, and the impact of bowel dysfunction on QoL after SCI.
methodsWe searched five databases to identify research assessing the influence of NBD or B-AD on QoL after SCI. Metrics of bowel dysfunction (fecal incontinence [FI], constipation, time to complete, and B-AD) and QoL data were extracted and synthesised. Where possible, meta-analyses were performed.
resultsOur search identified 2042 titles, of which 39 met our inclusion criteria. Individuals with SCI identified problems with NBD (74.7%), FI (56.9%), and constipation (54.6%), and 49.3% of individuals with SCI > T6 experienced B-AD. Additionally, 40.3% of individuals experienced prolonged defecation ( > 30 min). Moderate/severe deterioration in QoL due to NBD was reported by 55.5% of individuals with SCI, with negative impacts on physical, emotional, and social health-related QoL associated with inflexibility of bowel routines, fear of accidents, and loss of independence.
conclusionBowel dysfunction and bowel care challenges are prevalent and disabling for individuals with SCI, with a profoundly negative impact on QoL. Improving bowel management is a key target to improve QoL for those living with SCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.