ArticleNature chemistry2024
Template-based copying in chemically fuelled dynamic combinatorial libraries.
Article in Nature chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Increasing the Compositional Heterogeneity of Single-Chain Amphiphile Membranes Supported by Coacervate Cores Alters Stability and Properties of the Hybrid Protocells.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Light-Driven Competitive Selection in a Protein-Catalyzed Dissipative Peptide Replication.Angewandte Chemie (International ed. in English) · 2026Article
- Regulating Promiscuous Catalysis via Substrate-Induced Transient Assembly.Angewandte Chemie (International ed. in English) · 2026Article
- Design and applications of synthetic biomolecular condensates.Nature nanotechnology · 2026Review
- Programmable Multi-State Fluorescence Switching on a Dynamic Molecular System via Sequential Dynamic Covalent Chemistry and Applications.Precision chemistry · 2025Article
- Article
- An information ratchet improves selectivity in molecular recognition under non-equilibrium conditions.Nature nanotechnology · 2025Article
- Article
- Molecular Insight into Amyloid Fibril-Templated Aggregation of Biomarkers.ACS chemical neuroscience · 2025Article
- Metabolism-inspired chemical reaction networks for chemically driven dissipative oligoesterification.Angewandte Chemie (International ed. in English) · 2025Article
- Chemically Triggered Reactive Coacervates Show Life-Like Budding and Membrane Formation.Journal of the American Chemical Society · 2025Article
- Bioinspired and biomimetic nucleobase-containing polymers: the effect of selective multiple hydrogen bonds.Chemical science · 2024Review
- Template-based copying in chemically fuelled dynamic combinatorial libraries.Nature chemistry · 2024Article
- A template for artificial life.Nature chemistry · 2024Article
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Authors and funding
8 authors.
Funding
Abstract
One of science's greatest challenges is determining how life can spontaneously emerge from a mixture of molecules. A complicating factor is that life and its molecules are inherently unstable-RNA and proteins are prone to hydrolysis and denaturation. For the de novo synthesis of life or to better understand its emergence at its origin, selection mechanisms are needed for unstable molecules. Here we present a chemically fuelled dynamic combinatorial library to model RNA oligomerization and deoligomerization and shine new light on selection and purification mechanisms under kinetic control. In the experiments, oligomers can only be sustained by continuous production. Hybridization is a powerful tool for selecting unstable molecules, offering feedback on oligomerization and deoligomerization rates. Moreover, we find that templation can be used to purify libraries of oligomers. In addition, template-assisted formation of oligomers within coacervate-based protocells changes its compartment's physical properties, such as their ability to fuse. Such reciprocal coupling between oligomer production and physical properties is a key step towards synthetic life.
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