Evidence map›Paper›PMID 39013948›Full record

ArticleNature communications2024

Metabolic imaging across scales reveals distinct prostate cancer phenotypes.

Nikita Sushentsev, Gregory Hamm, Lucy Flint, Daniel Birtles, Aleksandr Zakirov, Jack Richings, Stephanie Ling, Jennifer Y Tan, Mary A McLean, Vinay Ayyappan and 10 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Article
  6. Advances in spatial omics for the analysis of prostate cancer.Analytical and bioanalytical chemistry · 2026
    Review
  7. Article
  8. Review
  9. Spatial metabolomics informs the use of clinical imaging for improved detection of cribriform prostate cancer.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Article
  12. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Nikita Sushentsev *Department of Radiology, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. ns784@medschl.cam.ac.uk.ORCID 0000-0003-4500-9714
Gregory Hamm *Integrated BioAnalysis, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
Lucy FlintIntegrated BioAnalysis, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
Daniel BirtlesIntegrated BioAnalysis, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, UK.ORCID 0000-0002-5915-806X
Aleksandr ZakirovDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Jack RichingsPredictive AI & Data, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
Stephanie LingIntegrated BioAnalysis, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, UK.ORCID 0000-0002-1237-091X
Jennifer Y TanPredictive AI & Data, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
Mary A McLeanDepartment of Radiology, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.ORCID 0000-0002-3752-0179
Vinay AyyappanDepartment of Radiology, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Ines Horvat MenihDepartment of Radiology, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Cara BrodieCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Jodi L MillerCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.ORCID 0000-0001-6870-204X
Ian G MillsPatrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.ORCID 0000-0001-5347-5083
Vincent J GnanapragasamDepartment of Urology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Anne Y WarrenDepartment of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.ORCID 0000-0002-1170-7867
Simon T BarryBioscience, Early Oncology, AstraZeneca, Cambridge, UK.ORCID 0000-0002-8511-0588
Richard J A GoodwinIntegrated BioAnalysis, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, UK.ORCID 0000-0001-5699-8488
Tristan BarrettDepartment of Radiology, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Ferdia A GallagherDepartment of Radiology, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Funding

Prostate Cancer UK PA14-012Wellcome Trust
6 · The paper itself

Abstract

Hyperpolarised magnetic resonance imaging (HP-

Indexed as

Lactic AcidMagnetic Resonance ImagingPhenotypeProstatic NeoplasmsCarbon IsotopesHumansL-Lactate DehydrogenaseMaleMitochondriaNeoplasm GradingProstateCarbon IsotopesLactic AcidL-Lactate Dehydrogenase

Identifiers

PMID39013948
PMCPMC11252279

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.