Evidence map›Paper›PMID 39013903›Full record

ArticleNature communications2024

Epidermal growth factor-like domain 7 drives brain lymphatic endothelial cell development through integrin αvβ3.

Jingying Chen, Jing Ding, Yongyu Li, Fujuan Feng, Yuhang Xu, Tao Wang, Jianbo He, Jing Cang, Lingfei Luo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jingying ChenSchool of Life Sciences, Department of Anaesthesia of Zhongshan Hospital, Fudan University, 200438, Shanghai, China. jingyingchen@fudan.edu.cn.ORCID 0009-0009-4051-4739
Jing DingInstitute of Developmental Biology and Regenerative Medicine, Southwest University, 400715, Chongqing, China.
Yongyu LiInstitute of Developmental Biology and Regenerative Medicine, Southwest University, 400715, Chongqing, China.
Fujuan FengInstitute of Developmental Biology and Regenerative Medicine, Southwest University, 400715, Chongqing, China.
Yuhang XuInstitute of Developmental Biology and Regenerative Medicine, Southwest University, 400715, Chongqing, China.
Tao WangInstitute of Developmental Biology and Regenerative Medicine, Southwest University, 400715, Chongqing, China.
Jianbo HeInstitute of Developmental Biology and Regenerative Medicine, Southwest University, 400715, Chongqing, China.
Jing CangSchool of Life Sciences, Department of Anaesthesia of Zhongshan Hospital, Fudan University, 200438, Shanghai, China.
Lingfei LuoSchool of Life Sciences, Department of Anaesthesia of Zhongshan Hospital, Fudan University, 200438, Shanghai, China. lluo@fudan.edu.cn.ORCID 0009-0000-4714-9169

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32322028
6 · The paper itself

Abstract

In zebrafish, brain lymphatic endothelial cells (BLECs) are essential for meningeal angiogenesis and cerebrovascular regeneration. Although epidermal growth factor-like domain 7 (Egfl7) has been reported to act as a pro-angiogenic factor, its roles in lymphangiogenesis remain unclear. Here, we show that Egfl7 is expressed in both blood and lymphatic endothelial cells. We generate an egfl7

Indexed as

BrainEndothelial CellsIntegrin alphaVbeta3LymphangiogenesisZebrafishZebrafish ProteinsAnimalsAnimals, Genetically ModifiedCell MovementCell ProliferationEGF Family of ProteinsGene Expression Regulation, DevelopmentalHumansMutationEGF Family of ProteinsEgfl7 protein, zebrafishIntegrin alphaVbeta3Zebrafish Proteins

Identifiers

PMID39013903
PMCPMC11252342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.