ArticleNature communications2024
Distinct neural mechanisms for heading retrieval and context recognition in the hippocampus during spatial reorientation.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Structured experience shapes strategy learning and neural dynamics in the medial entorhinal cortex.Nature neuroscience · 2026Article
- Complementary stable and dynamic prelimbic ensembles encode learned threat value underlying generalization and discrimination.bioRxiv : the preprint server for biology · 2026Article
- The relevance of context in memory tasks influences the magnitude of hippocampal remapping.Cell reports · 2025Article
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8 authors.
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Abstract
Reorientation, the process of regaining one's bearings after becoming lost, requires identification of a spatial context (context recognition) and recovery of facing direction within that context (heading retrieval). We previously showed that these processes rely on the use of features and geometry, respectively. Here, we examine reorientation behavior in a task that creates contextual ambiguity over a long timescale to demonstrate that male mice learn to combine both featural and geometric cues to recover heading. At the neural level, most CA1 neurons persistently align to geometry, and this alignment predicts heading behavior. However, a small subset of cells remaps coherently in a context-sensitive manner, which serves to predict context. Efficient heading retrieval and context recognition correlate with rate changes reflecting integration of featural and geometric information in the active ensemble. These data illustrate how context recognition and heading retrieval are coded in CA1 and how these processes change with experience.
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