Evidence map›Paper›PMID 39013632›Full record

ArticleBMJ open diabetes research & care2024

Environmental Determinants of Islet Autoimmunity (ENDIA) longitudinal prospective pregnancy to childhood cohort study of Australian children at risk of type 1 diabetes: parental demographics and birth information.

Rebecca L Thomson, Helena Oakey, Aveni Haynes, Maria E Craig, Leonard C Harrison, John M Wentworth, Amanda Anderson, Pat Ashwood, Simon Barry, Bek Brittain and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open diabetes research & care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Rebecca L ThomsonAdelaide Medical School, Faculty of Health and Medical Sciences and Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia r.thomson@adelaide.edu.au.ORCID 0000-0002-7807-4144
Helena OakeyAdelaide Medical School, Faculty of Health and Medical Sciences and Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0003-1057-7615
Aveni HaynesTelethon Kids Institute, Centre for Child Health Research, The University of Western Australia, Nedlands, Western Australia, Australia.ORCID 0000-0001-9954-5016
Maria E CraigInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.ORCID 0000-0001-6004-576X
Leonard C HarrisonWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID 0000-0002-2500-8944
John M WentworthWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID 0000-0002-5197-3529
Amanda AndersonAdelaide Medical School, Faculty of Health and Medical Sciences and Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia.
Pat AshwoodAdelaide Medical School, Faculty of Health and Medical Sciences and Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0003-4654-3281
Simon BarryAdelaide Medical School, Faculty of Health and Medical Sciences and Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0002-0597-7609
Bek BrittainCentre for Diabetes Research, Harry Perkins Institute of Medical Research, The University of Western Australia, Perth, Western Australia, Australia.
James D BrownAdelaide Medical School, Faculty of Health and Medical Sciences and Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0001-5190-4833
Peter G ColmanDepartment of Diabetes and Endocrinology, The Royal Melbourne Hospital, Parkville, Victoria, Australia.ORCID 0000-0001-8718-6175
Elizabeth A DavisTelethon Kids Institute, Centre for Child Health Research, The University of Western Australia, Nedlands, Western Australia, Australia.ORCID 0000-0003-4244-5473
Emma Hamilton-WilliamsFrazer Institute, The University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0003-4892-3691
Dao HuynhAdelaide Medical School, Faculty of Health and Medical Sciences and Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia.
Tony HuynhDepartment of Endocrinology and Diabetes, Queensland Children's Hospital, South Brisbane, Queensland, Australia.ORCID 0000-0002-7909-3670
Ki-Wook KimDiscipline of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0001-9579-6408
Kelly J McGormAdelaide Medical School, Faculty of Health and Medical Sciences and Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0002-7893-6998
Grant MorahanCentre for Diabetes Research, Harry Perkins Institute of Medical Research, The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0002-8562-7325
William RawlinsonDiscipline of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0003-0988-7827
Richard O SinnottMelbourne eResearch Group, School of Computing and Information Services, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0001-5998-222X
Georgia SoldatosSchool of Public Health and Preventive Medicine and School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.
Jason A Tye-DinWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID 0000-0001-7687-9654
Peter J VuillerminFaculty of Health, School of Medicine, Deakin University, Geelong, Victoria, Australia.ORCID 0000-0002-6580-0346
Megan A S PennoAdelaide Medical School, Faculty of Health and Medical Sciences and Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0002-9617-0826
Jennifer J CouperAdelaide Medical School, Faculty of Health and Medical Sciences and Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0003-4448-8629

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe Environmental Determinants of Islet Autoimmunity (ENDIA) Study is an ongoing Australian prospective cohort study investigating how modifiable prenatal and early-life exposures drive the development of islet autoimmunity and type 1 diabetes (T1D) in children. In this profile, we describe the cohort's parental demographics, maternal and neonatal outcomes and human leukocyte antigen (HLA) genotypes. RESEARCH DESIGN AND

methodsInclusion criteria were an unborn child, or infant aged less than 6 months, with a first-degree relative (FDR) with T1D. The primary outcome was persistent islet autoimmunity, with children followed until a T1D diagnosis or 10 years of age. Demographic data were collected at enrollment. Lifestyle, clinical and anthropometric data were collected at each visit during pregnancy and clinical pregnancy and birth data were verified against medical case notes. Data were compared between mothers with and without T1D. HLA genotyping was performed on the ENDIA child and all available FDRs.

resultsThe final cohort comprised 1473 infants born to 1214 gestational mothers across 1453 pregnancies, with 80% enrolled during pregnancy. The distribution of familial T1D probands was 62% maternal, 28% paternal and 11% sibling. The frequency of high-risk HLA genotypes was highest in T1D probands, followed by ENDIA infants, and lowest among unaffected family members. Mothers with T1D had higher rates of pregnancy complications and perinatal intervention, and larger babies of shorter gestation. Parent demographics were comparable to the Australian population for age, parity and obesity. A greater percentage of ENDIA parents were Australian born, lived in a major city and had higher socioeconomic advantage and education.

conclusionsThis comprehensive profile provides the context for understanding ENDIA's scope, methodology, unique strengths and limitations. Now fully recruited, ENDIA will provide unique insights into the roles of early-life factors in the development of islet autoimmunity and T1D in the Australian environment. TRIAL REGISTRATION NUMBER: ACTRN12613000794707.

Indexed as

AutoimmunityDiabetes Mellitus, Type 1AdultAustraliaChildChild, PreschoolFemaleFollow-Up StudiesGenotypeHLA AntigensHumansInfantInfant, NewbornIslets of LangerhansLongitudinal StudiesMaleHLA AntigensCohort StudiesDiabetes Mellitus, Type 1Islet AutoimmunityPregnancy

Identifiers

PMID39013632
PMCPMC11268074

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.