Evidence map›Paper›PMID 39013467›Full record

ArticleNeuron2024

Propofol anesthesia destabilizes neural dynamics across cortex.

Adam J Eisen, Leo Kozachkov, André M Bastos, Jacob A Donoghue, Meredith K Mahnke, Scott L Brincat, Sarthak Chandra, John Tauber, Emery N Brown, Ila R Fiete and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  5. Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  8. Observational
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  12. Adaptation modulates effective connectivity and network stability.Frontiers in computational neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Adam J EisenThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; The K. Lisa Yang Integrative Computational Neuroscience Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Leo KozachkovMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; The K. Lisa Yang Integrative Computational Neuroscience Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
André M BastosDepartment of Psychology, Vanderbilt University, Nashville, TN 37235, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37235, USA.
Jacob A DonoghueDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Beacon Biosignals, Boston, MA 02114, USA.
Meredith K MahnkeThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Scott L BrincatThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Sarthak ChandraMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; The K. Lisa Yang Integrative Computational Neuroscience Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
John TauberDepartment of Mathematics and Statistics, Boston University, Boston, MA 02215, USA.
Emery N BrownThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.
Ila R FieteMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; The K. Lisa Yang Integrative Computational Neuroscience Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: fiete@mit.edu.
Earl K MillerThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: ekmiller@mit.edu.

Funding

Non-Human Primate Model for Developing Closed-Loop Anesthesia Delivery SystemsR01NS123120 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI EMERY N BROWN · 2022 to 2026
$2.0M
Layer-specific manipulation to test feedforward/feedback cortical circuitryR01MH131715 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI EARL K MILLER · 2023 to 2026
$1.2M
Testing the Mechanisms, Layers, and Frequencies of Prediction Encoding and its ViolationR00MH116100 · NIMH · VANDERBILT UNIVERSITY · PI BASTOS, ANDRE MORAES · 2021 to 2023
$729k
NIMH NIH HHS R00 MH116100NIMH NIH HHS R01 MH131715NINDS NIH HHS R01 NS123120
6 · The paper itself

Abstract

Every day, hundreds of thousands of people undergo general anesthesia. One hypothesis is that anesthesia disrupts dynamic stability-the ability of the brain to balance excitability with the need to be stable and controllable. To test this hypothesis, we developed a method for quantifying changes in population-level dynamic stability in complex systems: delayed linear analysis for stability estimation (DeLASE). Propofol was used to transition animals between the awake state and anesthetized unconsciousness. DeLASE was applied to macaque cortex local field potentials (LFPs). We found that neural dynamics were more unstable in unconsciousness compared with the awake state. Cortical trajectories mirrored predictions from destabilized linear systems. We mimicked the effect of propofol in simulated neural networks by increasing inhibitory tone. This in turn destabilized the networks, as observed in the neural data. Our results suggest that anesthesia disrupts dynamical stability that is required for consciousness.

Indexed as

Anesthetics, IntravenousCerebral CortexPropofolAnimalsConsciousnessMacaca mulattaMaleModels, NeurologicalNerve NetNeuronsUnconsciousnessWakefulnessAnesthetics, IntravenousPropofolanesthesiaconsciousnessdynamical systemsdynamic stabilityKoopman operatorsneural dynamicsnon-human primatespropofolrecurrent neural networkstability

Identifiers

PMID39013467
PMCPMC11923585

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.