Evidence map›Paper›PMID 39013416›Full record

SynthesisOpen biology2024

Genetic evidence for serum amyloid P component as a drug target in neurodegenerative disorders.

A Floriaan Schmidt, Chris Finan, Sandesh Chopade, Stephan Ellmerich, Martin N Rossor, Aroon D Hingorani, Mark B Pepys

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Open biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Functional Amyloids in Adhesion of Non-Pathogens (Basel, Switzerland) · 2025
    Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

A Floriaan SchmidtInstitute of Cardiovascular Science, Faculty of Population Health, University College London, 69-75 Chenies Mews, London WC1E 6HX, UK.ORCID 0000-0003-1327-0424
Chris FinanInstitute of Cardiovascular Science, Faculty of Population Health, University College London, 69-75 Chenies Mews, London WC1E 6HX, UK.
Sandesh ChopadeInstitute of Cardiovascular Science, Faculty of Population Health, University College London, 69-75 Chenies Mews, London WC1E 6HX, UK.
Stephan EllmerichWolfson Drug Discovery Unit, Division of Medicine, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.
Martin N RossorUCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, Queen Square, London WC1N 3BG, UK.
Aroon D HingoraniInstitute of Cardiovascular Science, Faculty of Population Health, University College London, 69-75 Chenies Mews, London WC1E 6HX, UK.ORCID 0000-0001-8365-0081
Mark B PepysWolfson Drug Discovery Unit, Division of Medicine, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.ORCID 0000-0003-2614-3248

Funding

Bioinformatics Strategies for Genome-Wide Association StudiesR01LM010098 · NLM · UNIVERSITY OF PENNSYLVANIA · PI MOORE, JASON H., WILLIAMS, SCOTT MATTHEW · 2009 to 2023
$5.1M
British Heart Foundation PG/18/50/33837NLM NIH HHS R01 LM010098
6 · The paper itself

Abstract

The mechanisms responsible for neuronal death causing cognitive loss in Alzheimer's disease (AD) and many other dementias are not known. Serum amyloid P component (SAP) is a constitutive plasma protein, which is cytotoxic for cerebral neurones and also promotes formation and persistence of cerebral A

Indexed as

Genome-Wide Association StudyNeurodegenerative DiseasesSerum Amyloid P-ComponentAlzheimer DiseaseBiomarkersFemaleGenetic Predisposition to DiseaseHumansLewy Body DiseaseMaleMendelian Randomization AnalysisPolymorphism, Single Nucleotidetau ProteinsBiomarkersSerum Amyloid P-Componenttau ProteinsAlzheimer's diseaseC-reactive protein‌genome-wide association studyLewy body dementiamiridesapserum amyloid P component

Identifiers

PMID39013416
PMCPMC11251762

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.