Evidence map›Paper›PMID 39013379›Full record

ArticleThe American journal of tropical medicine and hygiene2024

Etiologies of Infectious Keratitis in Malawi.

Khumbo Kalua, Esther S Misanjo, Thomas M Lietman, Kevin Ruder, Lina Zhong, Cindi Chen, YuHeng Liu, Danny Yu, Thomas Abraham, Nathaniel Wu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Khumbo KaluaDepartment of Ophthalmology, Kamuzu College of Health Sciences, Blantyre, Malawi.
Esther S MisanjoDepartment of Ophthalmology, Kamuzu College of Health Sciences, Blantyre, Malawi.
Thomas M LietmanFrancis I. Proctor Foundation, University of California, San Francisco, California.
Kevin RuderFrancis I. Proctor Foundation, University of California, San Francisco, California.
Lina ZhongFrancis I. Proctor Foundation, University of California, San Francisco, California.
Cindi ChenFrancis I. Proctor Foundation, University of California, San Francisco, California.
YuHeng LiuFrancis I. Proctor Foundation, University of California, San Francisco, California.
Danny YuFrancis I. Proctor Foundation, University of California, San Francisco, California.
Thomas AbrahamFrancis I. Proctor Foundation, University of California, San Francisco, California.
Nathaniel WuFrancis I. Proctor Foundation, University of California, San Francisco, California.
Daisy YanFrancis I. Proctor Foundation, University of California, San Francisco, California.
Armin HinterwirthFrancis I. Proctor Foundation, University of California, San Francisco, California.
Thuy DoanFrancis I. Proctor Foundation, University of California, San Francisco, California.
Gerami D SeitzmanFrancis I. Proctor Foundation, University of California, San Francisco, California.

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAMBA, DEEPAK ASHOK · 1985 to 2024
$16.8M
UCSF-Proctor Clinician Vision Scholars K12 ProgramK12EY031372 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI THOMAS M LIETMAN, Yvonne Ou · 2020 to 2026
$3.9M
Improving Corneal Ulcer Outcomes with Unbiased Pathogen and Antimicrobial Resistance DetectionR01EY032861 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DOAN, THUY A · 2022 to 2025
$1.6M
NEI NIH HHS K12 EY031372NEI NIH HHS P30 EY002162NEI NIH HHS R01 EY032861
6 · The paper itself

Abstract

Infectious keratitis is a leading cause of corneal blindness worldwide with little information known about causative etiologies in Malawi, Africa. This area is resource-limited with ophthalmologist and microbiology services. The Department of Ophthalmology at the Kamuzu College of Health Sciences in Blantyre, Malawi, is a participating site of an international corneal ulcer consortium, capriCORN (Comprehensive Analysis of Pathogens, Resistomes, and Inflammatory-markers in the CORNea). In this study, 50 patients with corneal ulcers were swabbed for pathogen identification using RNA-sequencing. Corneal trauma was reported in 41% and 19% of the patients worked in agriculture. A pathogen was identified in 58% of the cases. Fungal pathogens predominated, followed by viruses and bacteria. Aspergillus, Fusarium, HSV-1, and Gardnerella were the most common pathogens detected. 50% of patients reported treatment with an antibiotic before presentation. Pathogens unusual for infectious keratitis, such as Subramaniula asteroids, Aureobasidium pullulans, and Gardnerella vaginalis, were also detected.

Indexed as

KeratitisAdolescentAdultAgedBacteriaCorneaCorneal UlcerEye Infections, FungalFemaleFungiHumansMalawiMaleMiddle AgedYoung Adult

Identifiers

PMID39013379
PMCPMC11376150

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.