Evidence map›Paper›PMID 39013134›Full record

ArticleJCO precision oncology2024

Differences in 21-Gene and PAM50 Recurrence Scores in Younger and Black Women With Breast Cancer.

Sarah C Van Alsten, Sanah N Vohra, Joannie M Ivory, Alina M Hamilton, Xiaohua Gao, Erin L Kirk, Eboneé N Butler, H Shelton Earp, Katherine E Reeder-Hayes, Katherine A Hoadley and 2 more

Abstract read
In one paragraph

Article in JCO precision oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sarah C Van AlstenLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0003-2131-6939
Sanah N VohraLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0003-4461-5157
Joannie M IvoryDivision of Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0003-3646-1178
Alina M HamiltonDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0001-9121-7114
Xiaohua GaoLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0003-4308-6126
Erin L KirkDepartment of Epidemiology, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0003-2709-0870
Eboneé N ButlerDepartment of Epidemiology, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.
H Shelton EarpLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0003-1229-4619
Katherine E Reeder-HayesLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0001-6903-0177
Katherine A HoadleyLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0002-1216-477X
Lisa A CareyLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0003-2388-4649
Melissa A TroesterLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0001-9506-6624

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
Tissue Procurement & PathologyP50CA058223 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHARLES M PEROU · 1992 to 2026
$59.3M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Reproduction, Lactation and Hormonal Factors in Breast Cancer SubtypesP01CA151135 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI AMBROSONE, CHRISTINE B., OLSHAN, ANDREW · 2011 to 2017
$18.1M
Cancer Control Education ProgramT32CA057726 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa B Gilkey, Melissa A. Troester · 2017 to 2026
$3.7M
P53, DNA Repair Imbalance, and Immune Response in Breast Cancer Mortality DisparitiesR01CA253450 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KATHERINE A. HOADLEY, Melissa A. Troester · 2021 to 2026
$3.6M
NCI NIH HHS P01 CA151135NCI NIH HHS P30 CA016086NCI NIH HHS P50 CA058223NCI NIH HHS R01 CA253450NCI NIH HHS T32 CA057726NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

purposeGenomic tests, such as the Oncotype Dx 21-gene and Prosigna risk of recurrence (ROR-P) assay, are commonly used for breast cancer prognostication. Emerging data suggest variability between assays, but this has not been compared in diverse populations. MATERIALS AND

methodsRNA sequencing was performed on 647 previously untreated stage I-III estrogen receptor-positive/human epidermal growth factor receptor 2-negative tumors in the Carolina Breast Cancer Study, which oversampled Black and younger women (age <50 years at diagnosis), using research versions of two common RNA-based prognostic assays: ROR-P

resultsAmong both younger and older individuals, Black women had higher frequency of intermediate and high ROR-P

conclusionROR-P

Indexed as

Breast NeoplasmsNeoplasm Recurrence, LocalAdultAgedAge FactorsBlack or African AmericanFemaleHumansMiddle AgedPrognosis

Identifiers

PMID39013134
PMCPMC11555617

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.