ArticlePloS one2024
Effectiveness of food supplement on treatment outcomes and quality of life in pulmonary tuberculosis: Phased implementation approach.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk factors for drug-induced liver injury in tuberculosis patients: a meta-analysis and systematic review.Frontiers in medicine · 2026Pooled it
- Food support for tuberculosis care: coverage, outcomes, and implementation lessons from thePublic health action · 2026Article
- Cost-effectiveness of in-kind nutritional support for impoverished persons with tuberculosis to reduce mortality and disengagement from care in India: a modelling study.BMJ global health · 2026Article
- Implementation of tuberculosis care cascade among adult people living with HIV registered in anti-retroviral therapy centres in Odisha, India, 2020-2023.BMC infectious diseases · 2026Article
- Article
- Development and external validation of a pre-treatment nomogram for predicting drug-induced liver injury risk in tuberculosis patients.Scientific reports · 2025Article
- Implementation of BMI field charts for nutritional assessment in adult patients with tuberculosis in Karnataka.Public health action · 2025Article
- A roadmap for integrating nutritional assessment, counselling, and support into the care of people with tuberculosis.The Lancet. Global health · 2025Review
- The ABCDs of Nutritional Assessment in Infectious Diseases Research.The Journal of infectious diseases · 2025Review
- Food insecurity in South Indian households with TB during COVID-19 lockdowns and the impact of nutritional interventions: A qualitative study.PLOS global public health · 2025Article
- Coverage, delivery models, and implementation challenges of the community driven nutritional supplementation initiative for people with TB: A mixed methods study from Puducherry, India.PLOS global public health · 2025Article
- Qualitative study of acceptability, benefits, and feasibility of a food-based intervention among participants and stakeholders of the RATIONS trial.PLOS global public health · 2025Article
- Mapping Drug-Resistant Tuberculosis Treatment Outcomes in Hunan Province, China.Tropical medicine and infectious disease · 2024Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBy encouraging treatment adherence and lowering mortality, dietary supplements can serve as adjuvant therapy for the success of medical interventions. We determined the effect of locally accessible food supplements on treatment outcomes, and health-related quality of life in patients with pulmonary tuberculosis initiating anti-tuberculosis treatment (ATT) in Odisha, India.
methodBetween September 2017 and December 2018, implementation research in patients with newly diagnosed sputum smear-positive pulmonary tuberculosis initiating ATT in five districts of the tribal belt of Odisha, offered food supplements along with ATT in a phased manner. Clinical symptoms, anthropometry, sputum for M. tuberculosis (M. tb), health-related quality of life and return to normal function were assessed periodically, and favourable treatment outcome (cure or treatment completed) was measured at the end of treatment. The effect of the food supplement on unfavorable outcomes (treatment failure, death, or lost-to-follow-up) was modelled using mixed-effects Poisson regression to determine the risk factors.
resultsAmong the 761 participants enrolled, 614 participants received the food supplement and 147 did not receive the food supplement. Among the 614 participants in the supplement group, 537 (87%) had a favorable outcome and among the 147 participants in the no-supplement group, 113 (77%) had a favorable outcome (p = 0.0017). Higher age (>55 years) [aRR = 2.1(95% CI: 1.1-3.8)], male gender [aRR = 1.7(95% CI: 1.2-2.9)], and smear grading ≥2+ [aRR = 1.5 (95% CI: 1.1-2.2)] were associated with unfavorable treatment outcomes. Nutritional status, quality of life and lung health showed significant improvement from baseline in the supplement group.
conclusionImprovement in the nutritional status of the patient can be considered a predictor of treatment success rates. Early food supplementation has a positive impact on the nutritional status.
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