Evidence map›Paper›PMID 39012826›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Transcriptional drift in aging cells: A global decontroller.

Tyler Matsuzaki, Corey Weistuch, Adam de Graff, Ken A Dill, Gábor Balázsi

Erratum issuedAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Human and bats genome robustness under COSMIC mutational signatures.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Tyler Matsuzaki *Louis and Beatrice Laufer Center for Physical and Quantitative Biology, Stony Brook University, New York, NY 11794.
Corey Weistuch *Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0001-6044-2511
Adam de GraffInVitro Cell Research, Englewood, NJ 07631.
Ken A DillLouis and Beatrice Laufer Center for Physical and Quantitative Biology, Stony Brook University, New York, NY 11794.ORCID 0000-0002-2390-2002
Gábor BalázsiLouis and Beatrice Laufer Center for Physical and Quantitative Biology, Stony Brook University, New York, NY 11794.ORCID 0000-0002-6865-5818

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Dynamics and evolution of synthetic and natural gene regulatory networksR35GM122561 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI BALAZSI, GABOR · 2017 to 2025
$4.2M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R35 GM122561SUNY | SBU | Laufer Center for Physical and Quantitative Biology, Stony Brook University (Laufer Center) N/A
6 · The paper itself

Abstract

As cells age, they undergo a remarkable global change: In transcriptional drift, hundreds of genes become overexpressed while hundreds of others become underexpressed. Using archetype modeling and Gene Ontology analysis on data from aging

Indexed as

Caenorhabditis elegansCellular SenescenceAgingAnimalsCaenorhabditis elegans ProteinsFibroblastsGene Expression RegulationHumansTranscription, GeneticCaenorhabditis elegans Proteinsagingarchetype analysistranscriptional drift

Identifiers

PMID39012826
PMCPMC11287169

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.